(R)-3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)-3-(but-3-enyl)cyclohexanone

Base Information

Chemical Name:(R)-3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)-3-(but-3-enyl)cyclohexanone
CAS No.:1402435-17-9
Molecular Formula:C₁₈H₂₀BrN₃O
Molecular Weight:374.28
Hs Code.:

Synonyms:(R)-3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)-3-(but-3-enyl)cyclohexanone

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Chemical Property of (R)-3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)-3-(but-3-enyl)cyclohexanone

Chemical Property:

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Technology Process of (R)-3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)-3-(but-3-enyl)cyclohexanone

There total 6 articles about (R)-3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)-3-(but-3-enyl)cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2101-88-4
1-azido-4-bromobenzene

: 1270183-50-0
(3R)-3-(but-3-enyl)-3-etynylcyclohexanone

: 1402435-17-9
(R)-3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)-3-(but-3-enyl)cyclohexanone

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; Inert atmosphere;
DOI:10.1002/chem.201200502

Reference yield:

: 930-68-7
cyclohexenone

: 1402435-17-9
(R)-3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)-3-(but-3-enyl)cyclohexanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: sodium periodate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; silica gel / dichloromethane / 20 °C / Inert atmosphere

3.1: C₁₈H₂₈N₂O⁽¹⁺⁾*Cl^(1-); copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 0.08 h / -10 °C / Inert atmosphere

3.2: 1 h / -10 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

5.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C / Inert atmosphere

With sodium periodate; n-butyllithium; copper(ll) sulfate pentahydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; C₁₈H₂₈N₂O⁽¹⁺⁾*Cl^(1-); tetrabutyl ammonium fluoride; silica gel; copper(II) bis(trifluoromethanesulfonate); sodium L-ascorbate; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/chem.201200502

Reference yield:

: 124267-26-1
3-ethynyl-2-cyclohexen-1-one

: 1402435-17-9
(R)-3-(1-(4-bromophenyl)-1H-1,2,3-triazol-4-yl)-3-(but-3-enyl)cyclohexanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: C₁₈H₂₈N₂O⁽¹⁺⁾*Cl^(1-); copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 0.08 h / -10 °C / Inert atmosphere

1.2: 1 h / -10 °C / Inert atmosphere

2.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C / Inert atmosphere

With copper(ll) sulfate pentahydrate; C₁₈H₂₈N₂O⁽¹⁺⁾*Cl^(1-); copper(II) bis(trifluoromethanesulfonate); sodium L-ascorbate; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/chem.201200502