(R,E)-4-(3-(2-(4-(5-(1,2-dithiolan-3-yl)pentanoyl)piperazin-1-yl)ethoxy)-3-oxoprop-1-enyl)-1,2-phenylene diacetate

Base Information

Chemical Name:(R,E)-4-(3-(2-(4-(5-(1,2-dithiolan-3-yl)pentanoyl)piperazin-1-yl)ethoxy)-3-oxoprop-1-enyl)-1,2-phenylene diacetate
CAS No.:1451180-85-0
Molecular Formula:C₂₇H₃₆N₂O₇S₂
Molecular Weight:564.724
Hs Code.:

Synonyms:(R,E)-4-(3-(2-(4-(5-(1,2-dithiolan-3-yl)pentanoyl)piperazin-1-yl)ethoxy)-3-oxoprop-1-enyl)-1,2-phenylene diacetate

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Chemical Property of (R,E)-4-(3-(2-(4-(5-(1,2-dithiolan-3-yl)pentanoyl)piperazin-1-yl)ethoxy)-3-oxoprop-1-enyl)-1,2-phenylene diacetate

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Technology Process of (R,E)-4-(3-(2-(4-(5-(1,2-dithiolan-3-yl)pentanoyl)piperazin-1-yl)ethoxy)-3-oxoprop-1-enyl)-1,2-phenylene diacetate

There total 3 articles about (R,E)-4-(3-(2-(4-(5-(1,2-dithiolan-3-yl)pentanoyl)piperazin-1-yl)ethoxy)-3-oxoprop-1-enyl)-1,2-phenylene diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1451180-79-2
C₁₄H₂₆N₂O₂S₂

: 82592-68-5,98631-72-2
(E)-3,4-di-O-acetylcaffeoyl chloride

: 1451180-85-0
(R,E)-4-(3-(2-(4-(5-(1,2-dithiolan-3-yl)pentanoyl)piperazin-1-yl)ethoxy)-3-oxoprop-1-enyl)-1,2-phenylene diacetate

Guidance literature:: C₁₄H₂₆N₂O₂S₂; With dmap; In dichloromethane; for 0.25h; Inert atmosphere;

(E)-3,4-di-O-acetylcaffeoyl chloride; In dichloromethane; for 3h; Inert atmosphere; Cooling with ice;
DOI:10.5012/bkcs.2013.34.4.1025

Reference yield:

: 1115175-97-7
2,5-dioxopyrrolidin-1-yl 5-(1,2-dithiolan-3-yl)pentanoate

: 1451180-85-0
(R,E)-4-(3-(2-(4-(5-(1,2-dithiolan-3-yl)pentanoyl)piperazin-1-yl)ethoxy)-3-oxoprop-1-enyl)-1,2-phenylene diacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Inert atmosphere

2.1: dmap / dichloromethane / 0.25 h / Inert atmosphere

2.2: 3 h / Inert atmosphere; Cooling with ice

With dmap; In dichloromethane;
DOI:10.5012/bkcs.2013.34.4.1025

Reference yield:

: 1200-22-2
(R)-1,2-dithiolane-3-pentanoic acid

: 1451180-85-0
(R,E)-4-(3-(2-(4-(5-(1,2-dithiolan-3-yl)pentanoyl)piperazin-1-yl)ethoxy)-3-oxoprop-1-enyl)-1,2-phenylene diacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / Inert atmosphere

2.1: Inert atmosphere

3.1: dmap / dichloromethane / 0.25 h / Inert atmosphere

3.2: 3 h / Inert atmosphere; Cooling with ice

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.5012/bkcs.2013.34.4.1025