Technology Process of R(+)-6-Chloro-7,8-dihydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
There total 5 articles about R(+)-6-Chloro-7,8-dihydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
boron tribromide;
In
hexane; dichloromethane;
1.) -70 deg C, 1 h, 2.) RT, 2 h;
DOI:10.1021/jm00116a004
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / trifluoroacetic acid, H2SO4 / 3 h / Heating
2: 69 percent / glacial acetic acid, bromine / 2 h / Ambient temperature
3: 85 percent / formic acid / 4 h / Heating
4: 1.) n-BuLi, 2.) hexachloroethane / 1.) Et2O, THF, -70 deg C, 10 min, 2.) Et2O, THF, -70 deg C, 5 min
5: 60 percent / boron tribromide / CH2Cl2; hexane / 1.) -70 deg C, 1 h, 2.) RT, 2 h
With
n-butyllithium; formic acid; hexachloroethane; sulfuric acid; bromine; boron tribromide; acetic acid; trifluoroacetic acid;
In
hexane; dichloromethane;
DOI:10.1021/jm00116a004
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 69 percent / glacial acetic acid, bromine / 2 h / Ambient temperature
2: 85 percent / formic acid / 4 h / Heating
3: 1.) n-BuLi, 2.) hexachloroethane / 1.) Et2O, THF, -70 deg C, 10 min, 2.) Et2O, THF, -70 deg C, 5 min
4: 60 percent / boron tribromide / CH2Cl2; hexane / 1.) -70 deg C, 1 h, 2.) RT, 2 h
With
n-butyllithium; formic acid; hexachloroethane; bromine; boron tribromide; acetic acid;
In
hexane; dichloromethane;
DOI:10.1021/jm00116a004
