methyl 2-methoxyimino-3-(4R-t-butoxycarbonylamino-2-cyclohexenylidene)propionate

Base Information

Chemical Name:methyl 2-methoxyimino-3-(4R-t-butoxycarbonylamino-2-cyclohexenylidene)propionate
CAS No.:190183-81-4
Molecular Formula:C₁₆H₂₄N₂O₅
Molecular Weight:324.377
Hs Code.:

Synonyms:methyl 2-methoxyimino-3-(4R-t-butoxycarbonylamino-2-cyclohexenylidene)propionate

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Chemical Property of methyl 2-methoxyimino-3-(4R-t-butoxycarbonylamino-2-cyclohexenylidene)propionate

Chemical Property:

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Technology Process of methyl 2-methoxyimino-3-(4R-t-butoxycarbonylamino-2-cyclohexenylidene)propionate

There total 8 articles about methyl 2-methoxyimino-3-(4R-t-butoxycarbonylamino-2-cyclohexenylidene)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 503817-77-4
methyl 2-methoxyimino-3-[(2R,3S,4R)-2,3-O-thiocarbonyldioxy-4-t-butoxycarbonylaminocyclohexylidene]propionate

: 190183-81-4
methyl 2-methoxyimino-3-(4R-t-butoxycarbonylamino-2-cyclohexenylidene)propionate

Guidance literature:: With 1,3-dimethyl-2-phenyl-1,3,2-diazaphospholidine; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 190183-81-4
methyl 2-methoxyimino-3-(4R-t-butoxycarbonylamino-2-cyclohexenylidene)propionate

Guidance literature:: Multi-step reaction with 8 steps

1: Et₃N

2: 5percent Na(Hg)

3: H₂ / Pd/C

4: DMSO, oxalyl chloride

5: 86 percent / n-BuLi / 1,2-dimethoxy-ethane

6: 83 percent / p-TsOH, H₂O / methanol

7: benzene

8: 1,3-dimethyl-2-phenyl-1,3,2-diazaphospholidine / CH₂Cl₂

With 1,3-dimethyl-2-phenyl-1,3,2-diazaphospholidine; n-butyllithium; sodium amalgam; oxalyl dichloride; water; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; dichloromethane; benzene;
DOI:10.1016/S0040-4039(97)00488-7

Reference yield:

: 138145-77-4
(1S,4R,7S,8S)-(+)-7,8-O-Isopropylidenedioxy-2-oxa-3-azabicyclo<2.2.2>oct-5-ene hydrochloride

: 190183-81-4
methyl 2-methoxyimino-3-(4R-t-butoxycarbonylamino-2-cyclohexenylidene)propionate

Guidance literature:: Multi-step reaction with 8 steps

1: Et₃N

2: 5percent Na(Hg)

3: H₂ / Pd/C

4: DMSO, oxalyl chloride

5: 86 percent / n-BuLi / 1,2-dimethoxy-ethane

6: 83 percent / p-TsOH, H₂O / methanol

7: benzene

8: 1,3-dimethyl-2-phenyl-1,3,2-diazaphospholidine / CH₂Cl₂

With 1,3-dimethyl-2-phenyl-1,3,2-diazaphospholidine; n-butyllithium; sodium amalgam; oxalyl dichloride; water; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; dichloromethane; benzene;
DOI:10.1016/S0040-4039(97)00488-7