138145-77-4

Upstream product

• 80409-75-2 cis-2,2-dimethyl-3a,7a-dihydrobenzo[1,3]dioxole 
• 95517-29-6 (-)-2,3:5,6-Di-O-isopropylidene-1-nitroso-α-D-manno-furanosyl chloride 

Downstream Products

• 503817-78-5 methyl 2-methoxyimino-3-(4R-acetamido-2-cyclohexenylidene)propionate 
• 190183-81-4 methyl 2-methoxyimino-3-(4R-t-butoxycarbonylamino-2-cyclohexenylidene)propionate 
• 190183-89-2 methyl 2-methoxyimino-3-[(2R,3S,4R)-2,3-dihydroxy-4-t-butoxycarbonylaminocyclohexylidene]propionate 
• 190183-92-7 methyl 2-methoxyimino-3-(4R-benzyloxycarbonylamino-2-cyclohexenylidene)propionate 
• 137775-71-4 (3S,4R,5S,6R)-(-)-3,4,5-Tris-6-phthalimidocyclohexene 
• 6730-25-2 (-)-1L-2,4-Diamino-2,4-dideoxychiroinositol dihydrochloride 
• 137775-70-3 (1S,2R,3S,6R)-(-)-6-Phthalimidocyclohex-4-ene-1,2,3-triol 
• 138513-22-1 dihydroconduramine A-1 
• 123808-78-6 (1S,2R,3S,4R)-(+)-4-Acetamidocyclohexane-1,2,3-triyl triacetate 
• 138513-21-0 (1S,2R,3S,6R)-6-aminocyclohex-4-ene-1,2,3-triol 

Relevant academic research and scientific papers

Total synthesis and absolute configuration of radiosumin, a strong trypsin inhibitor from the blue-green alga Plectonema radiosum

Radiosumin (1), a strong trypsin inhibitory dipeptide isolated from the freshwater blue-green alga Plectonema radiosum (NIES-515), was synthesized for the first time by use of the hetero Diels-Alder reaction, the Horner-Wadsworth-Emmons reaction, the Corey-Winter reaction, regioselective hydrogenation, and reduction with zinc and formic acid as key steps, which unambiguously determined the absolute configuration of the structurally unique and biologically intriguing aquatic natural product (1).

Asymmetric Synthesis of cis-1,3-Diamino-1,3-dideoxycyclitols

Starting with the hetero-Diels-Alder reaction of the O-isopropylidene-protected cis-cyclohexa-3,5-diene-1,2-diol with (-)-2,3:5,6-di-O-isopropylidene-1-nitroso-α-D-manno-furanosyl chloride the optically pure (+)-endo-adduct was exclusively formed.After re