(S)-3-(((R)-1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)diphenylsilyl)-2-methylpropanamide

Base Information

Chemical Name:(S)-3-(((R)-1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)diphenylsilyl)-2-methylpropanamide
CAS No.:1394293-53-8
Molecular Formula:C₃₂H₃₀N₂O₃Si
Molecular Weight:518.687
Hs Code.:

Synonyms:(S)-3-(((R)-1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)diphenylsilyl)-2-methylpropanamide

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Chemical Property of (S)-3-(((R)-1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)diphenylsilyl)-2-methylpropanamide

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Technology Process of (S)-3-(((R)-1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)diphenylsilyl)-2-methylpropanamide

There total 9 articles about (S)-3-(((R)-1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)diphenylsilyl)-2-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1394293-52-7
(S)-3-(((R)-1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)diphenylsilyl)-2-methylpropanoic acid

: 1394293-53-8
(S)-3-(((R)-1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)diphenylsilyl)-2-methylpropanamide

Guidance literature:: With ammonium hydroxide; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at -20 - -5 ℃; for 2h;
DOI:10.1021/ol301933n

Reference yield:

: 1394293-51-6
2-((R)-1-(((S)-2-methylbut-3-enyl)diphenylsilyl)-2-phenylethyl)isoindoline-1,3-dione

: 1394293-53-8
(S)-3-(((R)-1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)diphenylsilyl)-2-methylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; ozone / methanol; dichloromethane / -78 - 20 °C / Inert atmosphere

2.1: sodium dihydrogenphosphate; 2-methyl-but-2-ene / tert-butyl alcohol; water / 0.5 h

2.2: 2 h

3.1: triethylamine; chloroformic acid ethyl ester; ammonium hydroxide / tetrahydrofuran / 2 h / -20 - -5 °C

With ammonium hydroxide; sodium dihydrogenphosphate; 2-methyl-but-2-ene; chloroformic acid ethyl ester; ozone; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/ol301933n

Reference yield:

: C₃₂H₂₉NO₃Si

: 1394293-53-8
(S)-3-(((R)-1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)diphenylsilyl)-2-methylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium dihydrogenphosphate; 2-methyl-but-2-ene / tert-butyl alcohol; water / 0.5 h

1.2: 2 h

2.1: triethylamine; chloroformic acid ethyl ester; ammonium hydroxide / tetrahydrofuran / 2 h / -20 - -5 °C

With ammonium hydroxide; sodium dihydrogenphosphate; 2-methyl-but-2-ene; chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1021/ol301933n