N-((R)-1-(((S)-3-amino-2-methyl-3-oxopropyl)dihydroxysilyl)-2-phenylethyl)pyrrolidine-2-carboxamide

Base Information

Chemical Name:N-((R)-1-(((S)-3-amino-2-methyl-3-oxopropyl)dihydroxysilyl)-2-phenylethyl)pyrrolidine-2-carboxamide
CAS No.:1394293-55-0
Molecular Formula:C₁₇H₂₇N₃O₄Si
Molecular Weight:365.505
Hs Code.:

Synonyms:N-((R)-1-(((S)-3-amino-2-methyl-3-oxopropyl)dihydroxysilyl)-2-phenylethyl)pyrrolidine-2-carboxamide

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Chemical Property of N-((R)-1-(((S)-3-amino-2-methyl-3-oxopropyl)dihydroxysilyl)-2-phenylethyl)pyrrolidine-2-carboxamide

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Technology Process of N-((R)-1-(((S)-3-amino-2-methyl-3-oxopropyl)dihydroxysilyl)-2-phenylethyl)pyrrolidine-2-carboxamide

There total 11 articles about N-((R)-1-(((S)-3-amino-2-methyl-3-oxopropyl)dihydroxysilyl)-2-phenylethyl)pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1413776-17-6
C₁₇H₂₅F₂N₃O₂Si

: 1394293-55-0
N-((R)-1-(((S)-3-amino-2-methyl-3-oxopropyl)dihydroxysilyl)-2-phenylethyl)pyrrolidine-2-carboxamide

Guidance literature:: With sodium hydroxide; In dimethylsulfoxide-d6; water-d2; at 0 - 20 ℃; for 0.333333h;
DOI:10.1021/ol301933n

Reference yield:

: 1394293-52-7
(S)-3-(((R)-1-(1,3-dioxoisoindolin-2-yl)-2-phenylethyl)diphenylsilyl)-2-methylpropanoic acid

: 1394293-55-0
N-((R)-1-(((S)-3-amino-2-methyl-3-oxopropyl)dihydroxysilyl)-2-phenylethyl)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; chloroformic acid ethyl ester; ammonium hydroxide / tetrahydrofuran / 2 h / -20 - -5 °C

2.1: hydrazine / ethanol / 14 h / Reflux

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; 4-methyl-morpholine / dichloromethane; N,N-dimethyl-formamide / 14 h / -10 - 20 °C

4.1: trifluorormethanesulfonic acid / dichloromethane / 1 h / 0 °C

4.2: 0.5 h / 0 °C

5.1: hydrogen fluoride / dichloromethane / 0.17 h / pH 2 - 3

6.1: sodium hydroxide / dimethylsulfoxide-d6; water-d2 / 0.33 h / 0 - 20 °C

With 4-methyl-morpholine; ammonium hydroxide; trifluorormethanesulfonic acid; hydrogen fluoride; chloroformic acid ethyl ester; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; hydrazine; In tetrahydrofuran; dimethylsulfoxide-d6; ethanol; dichloromethane; water-d2; N,N-dimethyl-formamide;
DOI:10.1021/ol301933n

Reference yield:

: 1394293-51-6
2-((R)-1-(((S)-2-methylbut-3-enyl)diphenylsilyl)-2-phenylethyl)isoindoline-1,3-dione

: 1394293-55-0
N-((R)-1-(((S)-3-amino-2-methyl-3-oxopropyl)dihydroxysilyl)-2-phenylethyl)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triphenylphosphine; ozone / methanol; dichloromethane / -78 - 20 °C / Inert atmosphere

2.1: sodium dihydrogenphosphate; 2-methyl-but-2-ene / tert-butyl alcohol; water / 0.5 h

2.2: 2 h

3.1: triethylamine; chloroformic acid ethyl ester; ammonium hydroxide / tetrahydrofuran / 2 h / -20 - -5 °C

4.1: hydrazine / ethanol / 14 h / Reflux

5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; 4-methyl-morpholine / dichloromethane; N,N-dimethyl-formamide / 14 h / -10 - 20 °C

6.1: trifluorormethanesulfonic acid / dichloromethane / 1 h / 0 °C

6.2: 0.5 h / 0 °C

7.1: hydrogen fluoride / dichloromethane / 0.17 h / pH 2 - 3

8.1: sodium hydroxide / dimethylsulfoxide-d6; water-d2 / 0.33 h / 0 - 20 °C

With 4-methyl-morpholine; ammonium hydroxide; sodium dihydrogenphosphate; 2-methyl-but-2-ene; trifluorormethanesulfonic acid; hydrogen fluoride; chloroformic acid ethyl ester; ozone; triethylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; hydrazine; In tetrahydrofuran; methanol; dimethylsulfoxide-d6; ethanol; dichloromethane; water; water-d2; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/ol301933n