2-{[4-(2-acetylamino-2-allyloxycarbonyl-ethyl)-2-ethyl-phenyl]-tert-butoxyoxalyl-amino}-benzoic acid

Base Information

Chemical Name:2-{[4-(2-acetylamino-2-allyloxycarbonyl-ethyl)-2-ethyl-phenyl]-tert-butoxyoxalyl-amino}-benzoic acid
CAS No.:402924-99-6
Molecular Formula:C₂₉H₃₄N₂O₈
Molecular Weight:538.598
Hs Code.:

Synonyms:2-{[4-(2-acetylamino-2-allyloxycarbonyl-ethyl)-2-ethyl-phenyl]-tert-butoxyoxalyl-amino}-benzoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-{[4-(2-acetylamino-2-allyloxycarbonyl-ethyl)-2-ethyl-phenyl]-tert-butoxyoxalyl-amino}-benzoic acid

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Technology Process of 2-{[4-(2-acetylamino-2-allyloxycarbonyl-ethyl)-2-ethyl-phenyl]-tert-butoxyoxalyl-amino}-benzoic acid

There total 5 articles about 2-{[4-(2-acetylamino-2-allyloxycarbonyl-ethyl)-2-ethyl-phenyl]-tert-butoxyoxalyl-amino}-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 39061-59-1
t-butoxalyl chloride

: 592531-95-8
2-[4-(2-acetylamino-2-allyloxycarbonylethyl)-2-ethylphenylamino]-benzoic acid

: 402924-99-6
2-{[4-(2-acetylamino-2-allyloxycarbonyl-ethyl)-2-ethyl-phenyl]-tert-butoxyoxalyl-amino}-benzoic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/S0960-894X(03)00302-0

Reference yield:

: 436864-41-4
benzyl (2E)-2-(acetylamino)-3-(4-amino-3-ethylphenyl)-2-propenoate

: 402924-99-6
2-{[4-(2-acetylamino-2-allyloxycarbonyl-ethyl)-2-ethyl-phenyl]-tert-butoxyoxalyl-amino}-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / H₂ / 10 percent Pd/C / 20 °C / 3040 Torr

2: 62 percent / Cs₂CO₃ / 20 °C

3: 85 percent / Cu(OAc)2 / propan-2-ol / 80 °C

4: 72 percent / i-Pr₂NEt / CH₂Cl₂ / 0 - 20 °C

With copper diacetate; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In dichloromethane; isopropyl alcohol;
DOI:10.1016/S0960-894X(03)00302-0