3-iodo-N¹-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N²-(2-(1-(3-fluoro-4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)propan-2-yl)phthalamide

Base Information

• Chemical Name: 3-iodo-N¹-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N²-(2-(1-(3-fluoro-4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)propan-2-yl)phthalamide
• CAS No.: 1629909-36-9
• Molecular Formula: C₃₀H₂₄F₈IN₅O₃
• Molecular Weight: 781.444

Synonyms:3-iodo-N¹-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N²-(2-(1-(3-fluoro-4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)propan-2-yl)phthalamide

Chemical Property of 3-iodo-N¹-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N²-(2-(1-(3-fluoro-4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)propan-2-yl)phthalamide

Chemical Property:

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Technology Process of 3-iodo-N¹-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N²-(2-(1-(3-fluoro-4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)propan-2-yl)phthalamide

There total 5 articles about 3-iodo-N¹-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N²-(2-(1-(3-fluoro-4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)propan-2-yl)phthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-iodophthalic anhydride (28418-88-4) → 3-iodo-N1-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N2-(2-(1-(3-fluoro-4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)propan-2-yl)phthalamide (1629909-36-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetonitrile / 20 °C

2.1: trifluoroacetic anhydride / toluene / 0.5 h / 20 °C

2.2: 1 h / Cooling with ice

3.1: copper(l) iodide; triethylamine / ethyl acetate / 20 °C

With copper(l) iodide; triethylamine; trifluoroacetic anhydride; In ethyl acetate; toluene; acetonitrile;

DOI:10.1002/cjoc.201400202

Reference yield:

4-azido-2-fluoro-1-methoxybenzene (1052264-84-2) + 3-iodo-N1-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N2-(2-methylbut-3-yn-2-yl)phthalamide (1629909-41-6) → 3-iodo-N1-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N2-(2-(1-(3-fluoro-4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)propan-2-yl)phthalamide (1629909-36-9)

Guidance literature:

With copper(l) iodide; triethylamine; In ethyl acetate; at 20 ℃;

DOI:10.1002/cjoc.201400202

Reference yield:

3-iodo-2-((2-methylbut-3-yn-2-yl)carbamoyl)benzoic acid (1190702-87-4) → 3-iodo-N1-(2-methyl-4-(perfluoropropan-2-yl)phenyl)-N2-(2-(1-(3-fluoro-4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)propan-2-yl)phthalamide (1629909-36-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic anhydride / toluene / 0.5 h / 20 °C

1.2: 1 h / Cooling with ice

2.1: copper(l) iodide; triethylamine / ethyl acetate / 20 °C

With copper(l) iodide; triethylamine; trifluoroacetic anhydride; In ethyl acetate; toluene;

DOI:10.1002/cjoc.201400202

upstream raw materials:

3-iodophthalic anhydride

3-iodo-2-((2-methylbut-3-yn-2-yl)carbamoyl)benzoic acid

1,1-dimethylprop-3-ynylamine

3-fluoro-4-methoxyaniline

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