tetrahydro-4-[[4-[4-(trifluoromethyl)phenoxy]-1-piperidinyl]-sulfonyl]-2H-thiopyran-4-carboxylic acid

Base Information

Chemical Name:tetrahydro-4-[[4-[4-(trifluoromethyl)phenoxy]-1-piperidinyl]-sulfonyl]-2H-thiopyran-4-carboxylic acid
CAS No.:287953-08-6
Molecular Formula:C₁₈H₂₂F₃NO₅S₂
Molecular Weight:453.504
Hs Code.:

Synonyms:tetrahydro-4-[[4-[4-(trifluoromethyl)phenoxy]-1-piperidinyl]-sulfonyl]-2H-thiopyran-4-carboxylic acid

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Chemical Property of tetrahydro-4-[[4-[4-(trifluoromethyl)phenoxy]-1-piperidinyl]-sulfonyl]-2H-thiopyran-4-carboxylic acid

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Technology Process of tetrahydro-4-[[4-[4-(trifluoromethyl)phenoxy]-1-piperidinyl]-sulfonyl]-2H-thiopyran-4-carboxylic acid

There total 4 articles about tetrahydro-4-[[4-[4-(trifluoromethyl)phenoxy]-1-piperidinyl]-sulfonyl]-2H-thiopyran-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 287952-11-8
methyl [[4-[4-(trifluoromethyl)phenoxy]-1-piperidinyl]sulfonyl]acetate

: 7617-64-3
bis(2-bromoethyl)sulfide

: 10519-96-7
potassium trimethylsilonate

: 287953-08-6
tetrahydro-4-[[4-[4-(trifluoromethyl)phenoxy]-1-piperidinyl]-sulfonyl]-2H-thiopyran-4-carboxylic acid

Guidance literature:: With hydrogenchloride; potassium carbonate; In tetrahydrofuran; N-methyl-acetamide; water; ethyl acetate;

Reference yield:

: 287952-10-7
1-(methylsulfonyl)-4-[4-(trifluoromethyl)phenoxy]piperidine

: 287953-08-6
tetrahydro-4-[[4-[4-(trifluoromethyl)phenoxy]-1-piperidinyl]-sulfonyl]-2H-thiopyran-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium chloride; lithium hexamethyldisilazane / tetrahydrofuran

2: hydrogenchloride; potassium carbonate / tetrahydrofuran; N-methyl-acetamide; water; ethyl acetate

With hydrogenchloride; ammonium chloride; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; N-methyl-acetamide; water; ethyl acetate;

Reference yield:

: 28033-37-6
4-[4-(trifluoromethyl)-phenoxy]piperidine

: 287953-08-6
tetrahydro-4-[[4-[4-(trifluoromethyl)phenoxy]-1-piperidinyl]-sulfonyl]-2H-thiopyran-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / diethyl ether; dichloromethane; ethyl acetate

2: ammonium chloride; lithium hexamethyldisilazane / tetrahydrofuran

3: hydrogenchloride; potassium carbonate / tetrahydrofuran; N-methyl-acetamide; water; ethyl acetate

With hydrogenchloride; ammonium chloride; potassium carbonate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; N-methyl-acetamide; diethyl ether; dichloromethane; water; ethyl acetate;