28033-37-6

Usage

Uses

Used in Pharmaceutical Industry:
4-[4-(Trifluoromethoxy)phenoxy]piperidine is used as a key intermediate in the synthesis of substituted aminoquinolones. These aminoquinolones serve as DGKα (Diacylglycerol Kinase Alpha) inhibitors, which play a crucial role in immune activation. By inhibiting DGKα, these compounds can modulate the immune response, making them potentially valuable in the development of treatments for various immune-related conditions.

InChI:InChI=1/C12H14F3NO/c13-12(14,15)9-1-3-10(4-2-9)17-11-5-7-16-8-6-11/h1-4,11,16H,5-8H2

Upstream product

• 763884-90-8 4-(4-trifluoromethyl)phenoxy-N-methyl-piperidine 
• 98-56-6 4-chlorobenzotrifluoride 
• 287952-09-4 4-[4-(trifluoromethyl)phenoxy]piperidine hydrogen chloride salt 
• 287952-08-3 tert-butyl 4-(4-(trifluoromethyl)phenoxy)piperidine-1-carboxylate 
• 106-52-5 N-methyl-4-hydroxypiperidine 

Downstream Products

• 308386-12-1 2-[4-(4-trifluoromethyl-phenoxy)-piperidine-1-sulfonyl]-benzoic acid ethyl ester 
• 308386-20-1 1-(3,4-dimethoxy-benzenesulfonyl)-4-(4-trifluoromethyl-phenoxy)-piperidine 
• 308386-33-6 1-(3-chloro-benzenesulfonyl)-4-(4-trifluoromethyl-phenoxy)-piperidine 
• 1026583-69-6 1-[4-(tetrahydro-pyran-2-yloxy)-phenyl]-4-(4-trifluoromethyl-phenoxy)-piperidine 
• 681509-01-3 4-[4-(4-trifluoromethylphenoxy)piperidin-1-yl]phenol 
• 63843-72-1 1-[(5,6-dimethoxy-2-methyl-indol-3-yl)-oxo-acetyl]-4-(4-trifluoromethyl-phenoxy)-piperidine 

Relevant academic research and scientific papers

DERIVATIVES OF TRIAZINES AND URACILS, THEIR PREPARATION AND THEIR APPLICATION IN HUMAN THERAPEUTICS

The present invention relates to derivatives of general formula I wherein : - W represents nitrogen, - R1 represents: ? a hydrogen or a linear or branched C1-C5 alkyl radical or, ? a C1-C3 alkyl radical substituted with groups such as trifluoromethyl, nitrile, hydroxy, C1-C3 alcoxy, C3-C6 alkoxyalkoxy, indolyl, thiophenyl, oxothiophenyl, C1-C3 N-alkylcarbamoyl groups or, ? a phenyl or pyridyl or naphthyl, or thiophenyl group optionally substituted with one or more groups such as halogen atoms, nitro, nitrile, trifluoromethyl, vinyl, methylsulfanyl, linear branched C1-C4 alkyl, linear or branched C1-C3 alkoxy groups, ? a C6 2-oxocycloalkyl radical - R2 represents a methyl or heptyl, - m, n are equal to 1, - V represents CH2, - X-Y represents -N- (C=O) -, -CH-O-, - Z represents a phenyl group substituted with one or more trifluoromethyl groups, halogen atoms or linear C1-C4 alkyl groups.

MMP INHIBITORS AND METHODS OF USE THEREOF

Provided are MMP inhibitors having the Formula (I): wherein R1, R2 and Y are as defined herein, which are useful in the treatment and/or prevention of MMP-mediated diseases and disorders.

Synthesis of the rigid analogues of an SSRI benzenepropanamine

Several 1-(substituted phenoxy)-3-{4-(4-trifluoromethyl) phenoxy] piperidin-1-yl} propan-2-ols (str.II) were prepared in a six-step reaction sequence starting from methylamine and ethyl acrylate and evaluated for antidepressant activity. The compounds were fully characterized by spectral and elemental analyses, and were tested for their effect on gross behavior, antireserpine and anorexigenic activity. No effect was observed on gross behavior and some of them showed fluoxetine like antireserpine and anorexigenic activity. Birkhaeuser Boston 2005.

Sulfamato hydroxamic acid metalloprotease inhibitor

A sulfamato hydroxamic acid compound that, inter alia, inhibits matrix metalloprotease (mmp) activity is disclosed as are a process for preparing the same, intermediate compounds useful in those syntheses, and a treatment process that comprises administering a contemplated sulfamato hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.

Method of treating pain and hypertension

3-[2-(Phenyloxycycloazalkyl)ethyl]indoles possessing antihypertensive, analgesic, and tranquilizing properties and process for their preparation are described.