2-(4-nitro-1H-pyrrole-2-carbonyl)-N-(4-nitrophenyl)hydrazinecarboxamide

Base Information

• Chemical Name: 2-(4-nitro-1H-pyrrole-2-carbonyl)-N-(4-nitrophenyl)hydrazinecarboxamide
• CAS No.: 1616260-77-5
• Molecular Formula: C₁₂H₁₀N₆O₆
• Molecular Weight: 334.248
• Mol file: 1616260-77-5.mol

Synonyms:2-(4-nitro-1H-pyrrole-2-carbonyl)-N-(4-nitrophenyl)hydrazinecarboxamide

Chemical Property of 2-(4-nitro-1H-pyrrole-2-carbonyl)-N-(4-nitrophenyl)hydrazinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-nitro-1H-pyrrole-2-carbonyl)-N-(4-nitrophenyl)hydrazinecarboxamide

There total 3 articles about 2-(4-nitro-1H-pyrrole-2-carbonyl)-N-(4-nitrophenyl)hydrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-Nitrophenyl isocyanate (100-28-7) + 4-nitro-1H-pyrrole-2-carbohydrazide (28494-48-6) → 2-(4-nitro-1H-pyrrole-2-carbonyl)-N-(4-nitrophenyl)hydrazinecarboxamide (1616260-77-5)

Guidance literature:

In ethanol; N,N-dimethyl-formamide; Inert atmosphere; Reflux;

DOI:10.1016/j.bmcl.2014.05.018

Reference yield:

pyrrol-2-yl trichloromethyl ketone (35302-72-8) → 2-(4-nitro-1H-pyrrole-2-carbonyl)-N-(4-nitrophenyl)hydrazinecarboxamide (1616260-77-5)

Guidance literature:

Multi-step reaction with 3 steps

1: nitric acid; acetic anhydride / 2 h / -10 °C

2: hydrazine hydrate / ethanol / 2 h / 20 °C

3: ethanol; N,N-dimethyl-formamide / Inert atmosphere; Reflux

With nitric acid; acetic anhydride; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.05.018

Reference yield:

2,2,2-trichloro-1-(4-nitro-1H-pyrrol-2-yl)ethan-1-one (53391-50-7) → 2-(4-nitro-1H-pyrrole-2-carbonyl)-N-(4-nitrophenyl)hydrazinecarboxamide (1616260-77-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 2 h / 20 °C

2: ethanol; N,N-dimethyl-formamide / Inert atmosphere; Reflux

With hydrazine hydrate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2014.05.018

upstream raw materials:

4-Nitrophenyl isocyanate

4-nitro-1H-pyrrole-2-carbohydrazide

pyrrol-2-yl trichloromethyl ketone

2,2,2-trichloro-1-(4-nitro-1H-pyrrol-2-yl)ethan-1-one