3-((S)-4-Methyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid benzyl ester

Base Information

Chemical Name:3-((S)-4-Methyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid benzyl ester
CAS No.:852060-30-1
Molecular Formula:C₂₀H₂₆N₂O₄
Molecular Weight:358.437
Hs Code.:

Synonyms:3-((S)-4-Methyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid benzyl ester

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Chemical Property of 3-((S)-4-Methyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid benzyl ester

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Technology Process of 3-((S)-4-Methyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid benzyl ester

There total 6 articles about 3-((S)-4-Methyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 852060-27-6
3-((S)-4-Methyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester

: 100-51-6,185532-71-2
benzyl alcohol

: 852060-30-1
3-((S)-4-Methyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid benzyl ester

Guidance literature:: With 1-chloro-3-hydroxy-1,1,3,3-tetrabutyldistannoxane; In toluene; for 2h; Heating;
DOI:10.1021/jo050146m

Reference yield:

: 852059-99-5
(S)-2-(1-Cyano-cyclohexylamino)-pentanedioic acid dimethyl ester

: 852060-30-1
3-((S)-4-Methyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / sulfuric acid / CH₂Cl₂ / 1 h / 20 °C

2: 92 percent / Cs₂CO₃ / acetonitrile / 2 h / 50 °C

3: 76 percent / 3-chloro-1-hydroxytetrabutyldistannoxane / toluene / 2 h / Heating

With sulfuric acid; caesium carbonate; 1-chloro-3-hydroxy-1,1,3,3-tetrabutyldistannoxane; In dichloromethane; toluene; acetonitrile;
DOI:10.1021/jo050146m

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 852060-30-1
3-((S)-4-Methyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / CH₂Cl₂ / 3 h / 20 °C

1.2: 70 percent / ytterbium triflate / CH₂Cl₂ / 21 h / -23 - 20 °C

2.1: 55 percent / sulfuric acid / CH₂Cl₂ / 1 h / 20 °C

3.1: 92 percent / Cs₂CO₃ / acetonitrile / 2 h / 50 °C

4.1: 76 percent / 3-chloro-1-hydroxytetrabutyldistannoxane / toluene / 2 h / Heating

With sulfuric acid; caesium carbonate; 1-chloro-3-hydroxy-1,1,3,3-tetrabutyldistannoxane; triethylamine; In dichloromethane; toluene; acetonitrile; 1.2: Strecker reaction;
DOI:10.1021/jo050146m