3-((S)-3,5-Dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester

Base Information

• Chemical Name: 3-((S)-3,5-Dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester
• CAS No.: 852060-08-3
• Molecular Formula: C₁₃H₂₀N₂O₄
• Molecular Weight: 268.313

Synonyms:3-((S)-3,5-Dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester

Chemical Property of 3-((S)-3,5-Dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester

Chemical Property:

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Technology Process of 3-((S)-3,5-Dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester

There total 1 articles about 3-((S)-3,5-Dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

(S)-2-(1-Cyano-cyclohexylamino)-pentanedioic acid dimethyl ester (852059-99-5) → 3-((S)-3,5-Dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester (852060-08-3) + (S)-2-(1-Carbamoyl-cyclohexylamino)-pentanedioic acid dimethyl ester (852060-05-0)

Guidance literature:

With sulfuric acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jo050146m

Reference yield: 99.0%

3-((S)-3,5-Dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester (852060-08-3) + Benzyl bromoacetate (5437-45-6) → 3-((S)-4-Benzyloxycarbonylmethyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester (1054660-71-7)

Guidance literature:

With caesium carbonate; In acetonitrile; at 50 ℃; for 2h;

DOI:10.1021/jo050146m

Reference yield: 94.0%

3-((S)-3,5-Dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester (852060-08-3) + benzyl bromide (100-39-0) → 3-(4-benzyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-1-en-2-yl)-propionic acid methyl ester + 3-((S)-4-Benzyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester (852060-28-7)

Guidance literature:

With caesium carbonate; In acetonitrile; at 50 ℃; for 2h;

DOI:10.1021/jo050146m

upstream raw materials:

(S)-2-(1-Cyano-cyclohexylamino)-pentanedioic acid dimethyl ester

Downstream raw materials:

3-((S)-4-Benzyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester

3-((S)-4-Benzyloxycarbonylmethyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid methyl ester

3-((S)-4-Methyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid benzyl ester

3-((S)-4-Benzyl-3,5-dioxo-1,4-diaza-spiro[5.5]undec-2-yl)-propionic acid benzyl ester

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