ethyl 4-amino-6-oxo-1-phenyl-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

Base Information

• Chemical Name: ethyl 4-amino-6-oxo-1-phenyl-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate
• CAS No.: 344792-02-5
• Molecular Formula: C₁₅H₁₄N₄O₃
• Molecular Weight: 298.301

Synonyms:ethyl 4-amino-6-oxo-1-phenyl-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

Chemical Property of ethyl 4-amino-6-oxo-1-phenyl-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

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Technology Process of ethyl 4-amino-6-oxo-1-phenyl-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

There total 2 articles about ethyl 4-amino-6-oxo-1-phenyl-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

5-Amino-4-cyano-1-phenylpyrazole (5334-43-0) + diethyl malonate (105-53-3) → ethyl 4-amino-1-(phenyl)-6-hydroxy-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (344792-02-5)

Guidance literature:

With sodium ethanolate; In ethanol; for 7h; Reflux;

DOI:10.1080/00397910802517814

Reference yield: 42.0%

5-Amino-4-cyano-1-phenylpyrazole (5334-43-0) + diethyl malonate (105-53-3) → ethyl 4-amino-6-oxo-1-phenyl-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (344792-02-5)

Guidance literature:

5-Amino-4-cyano-1-phenylpyrazole; diethyl malonate; In toluene; for 1h; Reflux; Dean-Stark;

With tin(IV) chloride; In toluene; for 5h; Reflux; Dean-Stark;

DOI:10.1007/s10593-017-2041-9

Reference yield: 63.0%

ethyl 4-amino-6-oxo-1-phenyl-6,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (344792-02-5) → 4-Amino-1,7-dihydro-1-phenylpyrazolo[3,4-b]pyrdin-6-one + 4-amino-1,7-dihydro-1-phenylpyrazolo[3,4-b]pyridin-6-one (344792-03-6)

Guidance literature:

With hydrogenchloride; In sodium hydroxide; water;

upstream raw materials:

5-Amino-4-cyano-1-phenylpyrazole

diethyl malonate

Downstream raw materials:

4-amino-1,7-dihydro-1-phenylpyrazolo[3,4-b]pyridin-6-one

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