N-{2-[2-benzylidenehydrazinyl]-1-isopropyl-2-oxoethyl}-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Base Information

Chemical Name:N-{2-[2-benzylidenehydrazinyl]-1-isopropyl-2-oxoethyl}-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide
CAS No.:1613378-45-2
Molecular Formula:C₂₄H₂₇N₅O₃
Molecular Weight:433.51
Hs Code.:

Synonyms:N-{2-[2-benzylidenehydrazinyl]-1-isopropyl-2-oxoethyl}-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

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Chemical Property of N-{2-[2-benzylidenehydrazinyl]-1-isopropyl-2-oxoethyl}-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

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Technology Process of N-{2-[2-benzylidenehydrazinyl]-1-isopropyl-2-oxoethyl}-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

There total 5 articles about N-{2-[2-benzylidenehydrazinyl]-1-isopropyl-2-oxoethyl}-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1613378-42-9
1-ethyl-N-(1-hydrazinyl-3-methyl-1-oxobutan-2-yl)-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

: 100-52-7
benzaldehyde

: 1613378-45-2
N-{2-[2-benzylidenehydrazinyl]-1-isopropyl-2-oxoethyl}-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Guidance literature:: With acetic acid; Reflux;
DOI:10.5560/ZNB.2014-3282

Reference yield:

: 389-08-2
nalidixic Acid

: 1613378-45-2
N-{2-[2-benzylidenehydrazinyl]-1-isopropyl-2-oxoethyl}-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: chloroformic acid ethyl ester; triethylamine / dichloromethane / 0.17 h / -20 °C

2: dichloromethane / -20 - 20 °C

3: sodium hydroxide / ethanol / 14 h / -5 - 20 °C

4: hydrazine hydrate / methanol / 10 h / Reflux

5: acetic acid / Reflux

With chloroformic acid ethyl ester; hydrazine hydrate; acetic acid; triethylamine; sodium hydroxide; In methanol; ethanol; dichloromethane;
DOI:10.5560/ZNB.2014-3282

Reference yield:

: 174814-97-2
methyl 2-{[(1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridin-3-yl)carbonyl]amino}-3-methylbutanoate

: 1613378-45-2
N-{2-[2-benzylidenehydrazinyl]-1-isopropyl-2-oxoethyl}-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol / 14 h / -5 - 20 °C

2: hydrazine hydrate / methanol / 10 h / Reflux

3: acetic acid / Reflux

With hydrazine hydrate; acetic acid; sodium hydroxide; In methanol; ethanol;
DOI:10.5560/ZNB.2014-3282