Multi-step reaction with 10 steps
1.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran / 2.5 h / 0 °C
1.2: 2 h / 25 °C
2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 25 °C
3.1: dmap; triethylamine / dichloromethane / 12 h / 25 °C
4.1: boron tribromide / dichloromethane / 1.5 h / -78 - 25 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C
5.2: 20 °C
6.1: acetic anhydride; copper(II) nitrate hydrate / 3 h / 0 - 20 °C
7.1: sodium dithionite / water; tetrahydrofuran / 20 °C
8.1: dmap / N,N-dimethyl-formamide / 5 h / 20 °C
9.1: N,N,N,N,-tetramethylethylenediamine; diisopropylamine; n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C
9.2: 2 h / -100 - -20 °C
10.1: hydrogenchloride / 1,4-dioxane / 20 °C
With
2,2,6,6-tetramethyl-piperidine; hydrogenchloride; dmap; n-butyllithium; sodium dithionite; oxalyl dichloride; copper(II) nitrate hydrate; N,N,N,N,-tetramethylethylenediamine; acetic anhydride; boron tribromide; sodium hydride; triethylamine; diisopropylamine;
N,N-dimethyl-formamide;
In
tetrahydrofuran; 1,4-dioxane; hexanes; dichloromethane; water; N,N-dimethyl-formamide;