Technology Process of C26H33NO5
There total 3 articles about C26H33NO5 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3R)-3-propionyl-4-benzyloxazolidin-2-one;
With
di-n-butylboryl trifluoromethanesulfonate;
In
dichloromethane;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 0 ℃;
for 1h;
Inert atmosphere;
(3S)-5-(benzyloxy)-3-methylpentanal;
In
dichloromethane;
at -78 - 0 ℃;
for 6h;
stereoselective reaction;
Inert atmosphere;
DOI:10.1021/ol302309c
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / tert-butyl alcohol; water; tetrahydrofuran / 12 h / Inert atmosphere
1.2: 3 h / 0 - 20 °C / Inert atmosphere
2.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
2.2: 1 h / 0 °C / Inert atmosphere
2.3: 6 h / -78 - 0 °C / Inert atmosphere
With
osmium(VIII) oxide; di-n-butylboryl trifluoromethanesulfonate; 4-methylmorpholine N-oxide;
In
tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
2.1: |Evans Aldol Reaction / 2.2: |Evans Aldol Reaction / 2.3: |Evans Aldol Reaction;
DOI:10.1021/ol302309c
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) / toluene / 12 h / Reflux; Inert atmosphere
2.1: 4-methylmorpholine N-oxide; osmium(VIII) oxide / tert-butyl alcohol; water; tetrahydrofuran / 12 h / Inert atmosphere
2.2: 3 h / 0 - 20 °C / Inert atmosphere
3.1: di-n-butylboryl trifluoromethanesulfonate / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
3.2: 1 h / 0 °C / Inert atmosphere
3.3: 6 h / -78 - 0 °C / Inert atmosphere
With
osmium(VIII) oxide; 2,2'-azobis(isobutyronitrile); di-n-butylboryl trifluoromethanesulfonate; tri-n-butyl-tin hydride; 4-methylmorpholine N-oxide;
In
tetrahydrofuran; dichloromethane; water; toluene; tert-butyl alcohol;
1.1: |Barton-McCombie Deoxygenation / 3.1: |Evans Aldol Reaction / 3.2: |Evans Aldol Reaction / 3.3: |Evans Aldol Reaction;
DOI:10.1021/ol302309c
