Technology Process of Cbz-Arg(Mtr)-Gly-OMe
There total 3 articles about Cbz-Arg(Mtr)-Gly-OMe which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Z-Arg(Mtr)-OH;
With
benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.5h;
Inert atmosphere;
glycine ethyl ester hydrochloride;
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1002/chem.200902398
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium hydrogensulfate / ethyl acetate
2.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
With
potassium hydrogensulfate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/chem.200902398
