80745-08-0Relevant articles and documents
Cyclic RGD-peptidomimetics containing bifunctional diketopiperazine scaffolds as new potent integrin ligands
Da Ressurreica o, Ana Sofia M.,Vidu, Anamaria,Civera, Monica,Belvisi, Laura,Potenza, Donatella,Manzoni, Leonardo,Ongeri, Sandrine,Gennari, Cesare,Piarulli, Umberto
supporting information; experimental part, p. 12184 - 12188 (2011/12/16)
A perfect fit: The nanomolar affinity of a diketopiperazine-derived cyclic RGD-peptidomimetic for the integrin αvβ 3 receptor can be attributed to its high structural pre-organization. The transdiketopiperazine scaffold induces an extended RGD disposition permitting all important interactions with the extracellular domain of the αvβ 3 integrin. The metal ion in the metaliondependent adhesion site region is represented by a magenta sphere.
An approach toward the total synthesis of cyclotheonamides; preparation of a C(1) to N(14) segment
Wipf, Peter,Kim, Hong-Yong
, p. 4275 - 4278 (2007/10/02)
The C(1) to N(14) segment of the potent thrombin inhibitor cyclotheonamide A was prepared from L-arginine, L-proline, and L-asparagine. The arginine backbone was extended via a cyanohydrin, and the usual diaminopropanoic acid residue was obtained from hypervalent iodine oxidation of the asparagine side chain.
