N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-4-yl}-acetamide trifluoroacetic acid

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Chemical Name:N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-4-yl}-acetamide trifluoroacetic acid
CAS No.:1352872-34-4
Molecular Formula:C₂HF₃O₂*C₂₈H₂₃ClN₄O
Molecular Weight:580.994
Hs Code.:

Synonyms:N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-4-yl}-acetamide trifluoroacetic acid

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Chemical Property of N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-4-yl}-acetamide trifluoroacetic acid

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Technology Process of N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-4-yl}-acetamide trifluoroacetic acid

There total 6 articles about N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-4-yl}-acetamide trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 1352874-26-0
1-(4-bromo-phenyl)-3-(2-chloro-benzyl)-1,3-dihydro-benzoimidazol-2-ylideneamine

: 101251-09-6
(4-acetylaminophenyl)boronic acid

: 76-05-1
trifluoroacetic acid

: 1352872-34-4
N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-4-yl}-acetamide trifluoroacetic acid

Guidance literature:: 1-(4-bromo-phenyl)-3-(2-chloro-benzyl)-1,3-dihydro-benzoimidazol-2-ylideneamine; (4-acetylaminophenyl)boronic acid; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 150 ℃; for 0.283333h; Microwave irradiation;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 106-40-1
4-bromo-aniline

: 1352872-34-4
N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-4-yl}-acetamide trifluoroacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / 4 h / 150 °C / Microwave irradiaton

1.2: 0.25 h

2.1: tin(II) chloride dihdyrate / ethanol / 2.83 h / 70 °C

3.1: water; acetonitrile / 18 h / 20 °C

4.1: potassium iodide / acetonitrile / 0.17 h / 110 °C / Microwave irradiation

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.28 h / 150 °C / Microwave irradiation

With tin(II) chloride dihdyrate; sodium carbonate; triethylamine; potassium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; acetonitrile;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1352872-34-4
N-{4'-[3-(2-chloro-benzyl)-2-imino-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-4-yl}-acetamide trifluoroacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / 4 h / 150 °C / Microwave irradiaton

1.2: 0.25 h

2.1: tin(II) chloride dihdyrate / ethanol / 2.83 h / 70 °C

3.1: water; acetonitrile / 18 h / 20 °C

4.1: potassium iodide / acetonitrile / 0.17 h / 110 °C / Microwave irradiation

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 0.28 h / 150 °C / Microwave irradiation

With tin(II) chloride dihdyrate; sodium carbonate; triethylamine; potassium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; acetonitrile;