2-(4-methoxybenzyl)-1-(2-nitrobenzyl)-4-phenyl-1H-imidazole

Base Information

• Chemical Name: 2-(4-methoxybenzyl)-1-(2-nitrobenzyl)-4-phenyl-1H-imidazole
• CAS No.: 856659-43-3
• Molecular Formula: C₂₄H₂₁N₃O₃
• Molecular Weight: 399.449
• Mol file: 856659-43-3.mol

Synonyms:2-(4-methoxybenzyl)-1-(2-nitrobenzyl)-4-phenyl-1H-imidazole

Chemical Property of 2-(4-methoxybenzyl)-1-(2-nitrobenzyl)-4-phenyl-1H-imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-(4-methoxybenzyl)-1-(2-nitrobenzyl)-4-phenyl-1H-imidazole

There total 3 articles about 2-(4-methoxybenzyl)-1-(2-nitrobenzyl)-4-phenyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-(4-methoxybenzyl)-4-phenyl-1H-imidazole (901125-15-3) + 2-nitrophenylmethyl bromide (3958-60-9) → 2-(4-methoxybenzyl)-1-(2-nitrobenzyl)-4-phenyl-1H-imidazole (856659-43-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

DOI:10.1021/jo050384h

Reference yield:

4-Methoxyphenylacetic acid (104-01-8) → 2-(4-methoxybenzyl)-1-(2-nitrobenzyl)-4-phenyl-1H-imidazole (856659-43-3)

Guidance literature:

Multi-step reaction with 3 steps

1: CsCO₃ / dimethylformamide

2: 0.4 g / ammonium acetate / xylene / 1.5 h / Heating

3: 85 percent / NaH / dimethylformamide / 0.5 h / 20 °C

With ammonium acetate; sodium hydride; In N,N-dimethyl-formamide; xylene;

DOI:10.1021/jo050384h

Reference yield:

(4-Methoxy-phenyl)-acetic acid 2-oxo-2-phenyl-ethyl ester (132589-73-2) → 2-(4-methoxybenzyl)-1-(2-nitrobenzyl)-4-phenyl-1H-imidazole (856659-43-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.4 g / ammonium acetate / xylene / 1.5 h / Heating

2: 85 percent / NaH / dimethylformamide / 0.5 h / 20 °C

With ammonium acetate; sodium hydride; In N,N-dimethyl-formamide; xylene;

DOI:10.1021/jo050384h

upstream raw materials:

2-(4-methoxybenzyl)-4-phenyl-1H-imidazole

2-nitrophenylmethyl bromide

4-Methoxyphenylacetic acid

(4-Methoxy-phenyl)-acetic acid 2-oxo-2-phenyl-ethyl ester

Downstream raw materials:

2-[2-(4-methoxybenzyl)-4-phenylimidazol-1-ylmethyl]phenylamine