2-amino-2-[2-(4-octylphenyl)ethyl]-5-(tetrahydro-2H-pyran-2-yloxy)pentanol

Base Information

Chemical Name:2-amino-2-[2-(4-octylphenyl)ethyl]-5-(tetrahydro-2H-pyran-2-yloxy)pentanol
CAS No.:177260-26-3
Molecular Formula:C₂₆H₄₅NO₃
Molecular Weight:419.648
Hs Code.:

Synonyms:2-amino-2-[2-(4-octylphenyl)ethyl]-5-(tetrahydro-2H-pyran-2-yloxy)pentanol

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Chemical Property of 2-amino-2-[2-(4-octylphenyl)ethyl]-5-(tetrahydro-2H-pyran-2-yloxy)pentanol

Chemical Property:

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Technology Process of 2-amino-2-[2-(4-octylphenyl)ethyl]-5-(tetrahydro-2H-pyran-2-yloxy)pentanol

There total 17 articles about 2-amino-2-[2-(4-octylphenyl)ethyl]-5-(tetrahydro-2H-pyran-2-yloxy)pentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [1-hydroxymethyl-1-[2-(4-octyl-phenyl)-ethyl]-4-(tetrahydro-pyran-2-yloxy)-butyl]-carbamic acid methyl ester

: 177260-26-3
2-amino-2-[2-(4-octylphenyl)ethyl]-5-(tetrahydro-2H-pyran-2-yloxy)pentanol

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; for 13h; Heating;
DOI:10.1021/jm000173z

Reference yield:

: 33821-94-2
3-(tetrahydro-2H-pyran-2-yloxy)propyl bromide

: 177260-26-3
2-amino-2-[2-(4-octylphenyl)ethyl]-5-(tetrahydro-2H-pyran-2-yloxy)pentanol

Guidance literature:: Multi-step reaction with 9 steps

1.1: NaH / dimethylformamide / 0.5 h

1.2: 56 percent / dimethylformamide / 3 h

2.1: NaH / dimethylformamide / 0.5 h

2.2: 76 percent / dimethylformamide / 3 h

3.1: KOH / ethanol / 6 h / 50 °C

4.1: Et₃N / tetrahydrofuran / 0.25 h / -5 °C

5.1: aq. NaN₃ / tetrahydrofuran / 1 h / 0 °C

6.1: benzene / 1 h / Heating

7.1: benzene / 7 h / Heating

8.1: LiBH₄ / tetrahydrofuran / 3 h / Heating

9.1: 5 N aq. KOH / tetrahydrofuran; methanol / 13 h / Heating

With potassium hydroxide; lithium borohydride; sodium azide; sodium hydride; triethylamine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; benzene; 1.1: Metallation / 1.2: Alkylation / 2.1: Metallation / 2.2: Alkylation / 3.1: Hydrolysis / 4.1: Acylation / 5.1: Substitution / 6.1: Curtius rearrangement / 7.1: Addition / 8.1: Reduction / 9.1: Hydrolysis;
DOI:10.1021/jm000173z

Reference yield:

: 22455-91-0
diethyl 4-(tetrahydropyran-2-yloxy)butane-1,1-dicarboxylate

: 177260-26-3
2-amino-2-[2-(4-octylphenyl)ethyl]-5-(tetrahydro-2H-pyran-2-yloxy)pentanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: NaH / dimethylformamide / 0.5 h

1.2: 76 percent / dimethylformamide / 3 h

2.1: KOH / ethanol / 6 h / 50 °C

3.1: Et₃N / tetrahydrofuran / 0.25 h / -5 °C

4.1: aq. NaN₃ / tetrahydrofuran / 1 h / 0 °C

5.1: benzene / 1 h / Heating

6.1: benzene / 7 h / Heating

7.1: LiBH₄ / tetrahydrofuran / 3 h / Heating

8.1: 5 N aq. KOH / tetrahydrofuran; methanol / 13 h / Heating

With potassium hydroxide; lithium borohydride; sodium azide; sodium hydride; triethylamine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; benzene; 1.1: Metallation / 1.2: Alkylation / 2.1: Hydrolysis / 3.1: Acylation / 4.1: Substitution / 5.1: Curtius rearrangement / 6.1: Addition / 7.1: Reduction / 8.1: Hydrolysis;
DOI:10.1021/jm000173z