N-(4-methoxycarbonyl-2-methoxybenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorene

Base Information

Chemical Name:N-(4-methoxycarbonyl-2-methoxybenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorene
CAS No.:1431081-02-5
Molecular Formula:C₂₁H₂₁NO₃S
Molecular Weight:367.469
Hs Code.:

Synonyms:N-(4-methoxycarbonyl-2-methoxybenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-methoxycarbonyl-2-methoxybenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorene

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Technology Process of N-(4-methoxycarbonyl-2-methoxybenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorene

There total 2 articles about N-(4-methoxycarbonyl-2-methoxybenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 70264-94-7
methyl 4-(bromomethyl)-3-methoxybenzoate

: 7076-17-7
1,3,4,5-tetrahydrothiopyrano[4,3-b]indole

: 1431081-02-5
N-(4-methoxycarbonyl-2-methoxybenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorene

Guidance literature:: 1,3,4,5-tetrahydrothiopyrano[4,3-b]indole; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.5h; Inert atmosphere;

methyl 4-(bromomethyl)-3-methoxybenzoate; With potassium iodide; In N,N-dimethyl-formamide; mineral oil; at 80 ℃; for 2h; Inert atmosphere;
DOI:10.1039/c3cc41422a

Reference yield:

: 1072-72-6
Tetrahydrothiopyran-4-one

: 1431081-02-5
N-(4-methoxycarbonyl-2-methoxybenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorene

Guidance literature:: Multi-step reaction with 2 steps

1.1: bismuth (III) nitrate pentahydrate / methanol / 2 h / Reflux

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / Inert atmosphere

2.2: 2 h / 80 °C / Inert atmosphere

With bismuth (III) nitrate pentahydrate; sodium hydride; In methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c3cc41422a

Reference yield: 65.0%

: 1431081-02-5
N-(4-methoxycarbonyl-2-methoxybenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorene

: 1431080-94-2
N-(4-hydroxycarbamoyl-2-methoxybenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorene

Guidance literature:: With hydroxylamine hydrochloride; sodium methylate; In methanol; N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1039/c3cc41422a