Dimiracetam

Base Information

• Chemical Name: Dimiracetam
• CAS No.: 126100-97-8
• Molecular Formula: C6H8 N2 O2
• Molecular Weight: 140.142
• UNII: 4AW7F70MZO
• DSSTox Substance ID: DTXSID20869732
• Nikkaji Number: J569.485J
• Wikipedia: Dimiracetam
• Wikidata: Q3707748
• NCI Thesaurus Code: C79121
• Metabolomics Workbench ID: 153895
• ChEMBL ID: CHEMBL337612
• Mol file: 126100-97-8.mol

Synonyms:dihydro-1H-pyrrolo(1,2-a)imidazole-2,5-(3H,6H)-dione;dimiracetam

Chemical Property of Dimiracetam

Chemical Property:

• Vapor Pressure: 1.16E-08mmHg at 25°C
• Boiling Point: 460.5°C at 760 mmHg
• Flash Point: 232.3°C
• PSA: 52.90000
• Density: 1.4g/cm³
• LogP: -0.72150
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 140.058577502
• Heavy Atom Count: 10
• Complexity: 202

Purity/Quality:

99% ^*data from raw suppliers

DIHYDRO-1H-PYRROLO[1,2-A]IMIDAZOLE-2,5(3H,6H)-DIONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(=O)N2C1NC(=O)C2
• Recent ClinicalTrials: Dimiracetam in Painful Neuropathies Affecting AIDS Patients

Technology Process of Dimiracetam

There total 6 articles about Dimiracetam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methyl 1-benzyl-4-oxo-2-imidazolidinepropanoate (153393-25-0) → Dimiracetam (126100-97-8)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; water; for 3h; Heating;

DOI:10.1021/jm00078a011

Reference yield: 22.6%

glycinamide hydrochloride (1668-10-6) + 2'-methylpropyl 3-oxopropionate (126101-13-1) → Dimiracetam (126100-97-8)

Guidance literature:

With sodium hydroxide; for 20h; Heating; pH 9.5;

DOI:10.1021/jm00078a011

Reference yield:

isobutyl 5-oxo-2-imidazolidinepropanoate hydrochloride → Dimiracetam (126100-97-8)

Guidance literature:

With sodium bicarbonate; In water;

upstream raw materials:

glycinamide hydrochloride

2'-methylpropyl 3-oxopropionate

methyl 1-benzyl-4-oxo-2-imidazolidinepropanoate

Downstream raw materials:

2,5-dioxohexahydro-1H-pyrrolo[1,2-a]imidazole-1-acetamide

Refernces

• 1、 Pinza,Farina,Cerri,Pfeiffer,Riccaboni,Banfi,Biagetti,Pozzi,Magnani,Dorigotti. "Synthesis and pharmacological activity of a series of dihydro-1H- pyrrolo[1,2-a]imidazole-2,5(3H,6H)-diones, a novel class of potent cognition enhancers". . p. 4214 - 4220. Retrieved 2007/10/02.
• 2、 -. "Condensed imidazole derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them.". . . Retrieved 2008/06/13.