Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1668-10-6

Post Buying Request

1668-10-6 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1668-10-6 Usage

Chemical Properties

Crystalline

Uses

Different sources of media describe the Uses of 1668-10-6 differently. You can refer to the following data:
1. Glycinamide hydrochloride is a buffer that is useful in the physiological pH range. And it is also used as a pharmaceutical intermediate, in the organic synthesis.
2. Glycinamide hydrochloride may be used in the synthesis of [M(glycinamidato-N,N′)(ptpy)2] where ptpy = 2-(p-tolyl)pyridinato) and M= Rh or Ir. It may be used in the synthesis of the following glycinamide-based imidazolidinones:(±)-2-(2-phenylpropyl)imidazolidin-4-one(±)-2-(2,4,4-trimethylpentyl)imidazolidin-4-one (±)-2-[(R)-2,6-dimethyl-5-heptenyl]imidazolidin-4-one (5R,6S,9R)-6-isopropyl-9-methyl-1,4-diazaspiro[4.5]decan-2-one(5S,6S,9R)-6-isopropyl-9-methyl-1,4-diazaspiro[4.5]decan-2-one(±)-2-methyl-2-pentylimidazolidin-4-one(±)-2-ethyl-2-(2-methylbutyl)imidazolidin-4-one (±)-2-(undecan-2-yl)imidazolidin-4-one (±)-2-pentylimidazolidin-4-one 2-(2,4-dimethylcyclohex-3-en-1-yl)imidazolidin-4-one

Purification Methods

Crystallise the salt from EtOH, EtOH/H2O or MeOH. [Karmas & Spoerri J Am Chem Soc 74 1580 1952, Beilstein 4 IV 2358.]

Check Digit Verification of cas no

The CAS Registry Mumber 1668-10-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,6 and 8 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1668-10:
(6*1)+(5*6)+(4*6)+(3*8)+(2*1)+(1*0)=86
86 % 10 = 6
So 1668-10-6 is a valid CAS Registry Number.
InChI:InChI=1/C2H6N2O/c3-1-2(4)5/h1,3H2,(H2,4,5)/p+1

1668-10-6 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A11128)  Glycinamide hydrochloride, 98%   

  • 1668-10-6

  • 5g

  • 315.0CNY

  • Detail
  • Alfa Aesar

  • (A11128)  Glycinamide hydrochloride, 98%   

  • 1668-10-6

  • 25g

  • 938.0CNY

  • Detail
  • Alfa Aesar

  • (A11128)  Glycinamide hydrochloride, 98%   

  • 1668-10-6

  • 100g

  • 3002.0CNY

  • Detail

1668-10-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name Glycinamide hydrochloride

1.2 Other means of identification

Product number -
Other names Acetamide, 2-amino-, monohydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1668-10-6 SDS

1668-10-6Synthetic route

2-aminoacetonitrile
540-61-4

2-aminoacetonitrile

glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; 2-hydroxyethanethiol In tetrahydrofuran at -78℃;86%
Chloroacetamide
79-07-2

Chloroacetamide

glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

Conditions
ConditionsYield
With ammonia In ethanol at 100℃; for 0.5h;76%
4-methylene-1-oxa-6,9-diazaspiro<4,5>decane-7,10-dione
141509-41-3

4-methylene-1-oxa-6,9-diazaspiro<4,5>decane-7,10-dione

A

glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

B

3-hydroxy-4-(2-hydroxyethyl)-2(5H)-furanone
114533-59-4

3-hydroxy-4-(2-hydroxyethyl)-2(5H)-furanone

Conditions
ConditionsYield
With hydrogenchloride at 100℃; for 1.5h; Product distribution; other conditions, other reagents;A 33%
B 56%
2-amino-acetimidic acid methyl ester; dihydrochloride

2-amino-acetimidic acid methyl ester; dihydrochloride

glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

Conditions
ConditionsYield
bei dreiwoechigem Aufbewahren;
glycine ethyl ester hydrochloride
5680-79-5

glycine ethyl ester hydrochloride

glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

Conditions
ConditionsYield
With ammonia In methanol for 72h; Ambient temperature;
glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

N-Benzyloxycarbonyl-L-proline
1148-11-4

N-Benzyloxycarbonyl-L-proline

Nα-benzyloxycarbonyl-L-prolyl-glycinamide
35010-96-9

Nα-benzyloxycarbonyl-L-prolyl-glycinamide

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;100%
Stage #1: N-Benzyloxycarbonyl-L-proline With 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃;
Stage #2: glycinamide hydrochloride With triethylamine In tetrahydrofuran at 20℃; Further stages.;
53%
With 4-methyl-morpholine; isobutyl chloroformate 1) DMF, -15 deg C, 15 min, 2) -10 deg C, 14h; Yield given. Multistep reaction;
glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

N-(benzyloxycarbonyl)-L-phenylalanine benzyl ester
60379-01-3

N-(benzyloxycarbonyl)-L-phenylalanine benzyl ester

Z-L-phenylalanylglycinamide
17187-05-2

Z-L-phenylalanylglycinamide

Conditions
ConditionsYield
With S166C-SBnCOOH; triethylamine; calcium chloride In water; N,N-dimethyl-formamide for 1h; Ambient temperature;100%
With triethylamine; enzyme mutant SBL-S166C-S-[(4S,5R)-indenooxazolidinonyl] In water; N,N-dimethyl-formamide at 20℃; for 1h; pH=5.8;100%
With triethylamine; S166C-S-S-(CH2)2-O-β-D-Glc(Ac)2 subtilisin protease In water; N,N-dimethyl-formamide at 20℃; for 1h; pH=5.8; Enzymatic reaction; MES buffer;95%
With subtilisin BPN'; triethylamine In water; N,N-dimethyl-formamide Ambient temperature;80%
Z-L-GluOMe
5672-83-3

Z-L-GluOMe

glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

Z-L-Glu-Gly-NH2
126530-12-9

Z-L-Glu-Gly-NH2

Conditions
ConditionsYield
With S166C-SCH2CH2NH3+; triethylamine; calcium chloride In water; N,N-dimethyl-formamide for 5h; Ambient temperature;100%
With triethylamine; enzyme mutant SBL-S166C-S-CH2C(CH2NH3)3 In water; N,N-dimethyl-formamide at 20℃; for 5h; pH=5.8;71%
With triethylamine; S166C-S-S-(CH2)2-O-β-D-Gal subtilisin protease In water; N,N-dimethyl-formamide at 20℃; for 5h; pH=5.8; Enzymatic reaction; MES buffer;67%
glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide
82911-69-1

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Fmoc-Gly-NH2
115057-37-9

Fmoc-Gly-NH2

Conditions
ConditionsYield
With sodium carbonate In acetone at 20℃; for 1h;100%
With sodium hydrogencarbonate In acetone at 20℃; for 2h; pH=7;80%
With sodium carbonate In water; acetone at 0 - 20℃; for 1.5h;72%
6-bromopyrazolo[1,5-a]pyrimidine-3-carboxylic acid
912773-22-9

6-bromopyrazolo[1,5-a]pyrimidine-3-carboxylic acid

glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

N-(2-amino-2-oxoethyl)-6-bromopyrazolo[1,5-a]pyrimidine-3-carboxamide
1065082-89-4

N-(2-amino-2-oxoethyl)-6-bromopyrazolo[1,5-a]pyrimidine-3-carboxamide

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N,N-dimethyl-formamide at 20℃; for 2h;100%
sodium 1-(2,5-dimethoxyphenyl)-3-ethoxy-3-oxoprop-1-en-1-olate
1435472-77-7

sodium 1-(2,5-dimethoxyphenyl)-3-ethoxy-3-oxoprop-1-en-1-olate

glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

ethyl (Z)-3-( (2-amino-2-oxoethyl)amino)-3-(2,5-dimethoxyphenyl)acrylate
1435472-78-8

ethyl (Z)-3-( (2-amino-2-oxoethyl)amino)-3-(2,5-dimethoxyphenyl)acrylate

Conditions
ConditionsYield
Stage #1: glycinamide hydrochloride With sodium methylate at 65℃; for 1h;
Stage #2: sodium 1-(2,5-dimethoxyphenyl)-3-ethoxy-3-oxoprop-1-en-1-olate With acetic acid at 10℃; for 16.5h;
100%
glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

2,2,2-trifluoroethyl ((benzyloxy)carbonyl)-L-phenylalaninate
126028-14-6

2,2,2-trifluoroethyl ((benzyloxy)carbonyl)-L-phenylalaninate

A

N-Cbz-L-Phe
1161-13-3

N-Cbz-L-Phe

B

Z-L-phenylalanylglycinamide
17187-05-2

Z-L-phenylalanylglycinamide

Conditions
ConditionsYield
With Tris buffer; TEA; Celite; α-chymotrypsin In acetonitrile at 30℃; for 1h;A 0.6%
B 99%
glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

Nα-benzyloxycarbonyl-L-lysine thiobenzyl ester
69861-90-1

Nα-benzyloxycarbonyl-L-lysine thiobenzyl ester

Z-L-Lys-Gly-NH2

Z-L-Lys-Gly-NH2

Conditions
ConditionsYield
With S166C-SBnCOOH; triethylamine; calcium chloride In water; N,N-dimethyl-formamide for 5h; Ambient temperature;99%
glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

Z-L-Ala benzyl ester
88718-12-1

Z-L-Ala benzyl ester

CBZ-L-alanylglycinamide
4976-59-4

CBZ-L-alanylglycinamide

Conditions
ConditionsYield
With triethylamine; enzyme mutant SBL-S166C-S-(CH2)2-NMe3(1+) In water; N,N-dimethyl-formamide at 20℃; for 5h; pH=5.8;99%
With S166C-SBn; triethylamine; calcium chloride In water; N,N-dimethyl-formamide for 5h; Ambient temperature;95%
With triethylamine; S166C-S-S-(CH2)2-O-β-D-Gal(Ac)3 subtilisin protease In water; N,N-dimethyl-formamide at 20℃; for 5h; pH=5.8; Enzymatic reaction; MES buffer;92%
glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

Boc-His(Tos)-OH
35899-43-5

Boc-His(Tos)-OH

N-Boc-Nim-tosylhistidylglycinamide

N-Boc-Nim-tosylhistidylglycinamide

Conditions
ConditionsYield
With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran for 24h; slowly from 0 deg C to room temp.;98%
glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

(S)-1-((benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid
192214-00-9

(S)-1-((benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid

C15H19N3O4
1352661-21-2

C15H19N3O4

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In acetonitrile at 0 - 20℃; for 24h; Inert atmosphere;98%
glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

<<6-methoxy-5-(trifluoromethyl)-1-naphthalenyl>sulfonyl>chloride
113699-68-6

<<6-methoxy-5-(trifluoromethyl)-1-naphthalenyl>sulfonyl>chloride

2-<<<6-methoxy-5-(trifluoromethyl)-1-naphthalenyl>sulfonyl>amino>acetamide

2-<<<6-methoxy-5-(trifluoromethyl)-1-naphthalenyl>sulfonyl>amino>acetamide

Conditions
ConditionsYield
With sodium carbonate In 1,4-dioxane for 1h; Ambient temperature;97.8%
3-{4-fluoro-2-[3-(trifluoromethyl)benzyl]-1-benzothien-7-yl}benzoic acid
1207971-26-3

3-{4-fluoro-2-[3-(trifluoromethyl)benzyl]-1-benzothien-7-yl}benzoic acid

glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

N-(2-amino-2-oxoethyl)-3-{4-fluoro-2-[3-(trifluoromethyl)-benzyl]-1-benzothiophen-7-yl}benzamide
1207965-95-4

N-(2-amino-2-oxoethyl)-3-{4-fluoro-2-[3-(trifluoromethyl)-benzyl]-1-benzothiophen-7-yl}benzamide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 0 - 20℃; for 1h; Inert atmosphere;97%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 5h;60%
glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

acryloyl chloride
814-68-6

acryloyl chloride

N-acryloyl glycinamide
2479-62-1

N-acryloyl glycinamide

Conditions
ConditionsYield
With potassium carbonate In water; acetonitrile at 5 - 30℃; for 7h; Reagent/catalyst; Solvent;97%
Stage #1: glycinamide hydrochloride With potassium carbonate In water
Stage #2: acryloyl chloride In diethyl ether; water at 5 - 20℃;
72%
With potassium carbonate In dichloromethane at 5 - 20℃; pH=7 - 8;68%
m-bromobenzoic acid
585-76-2

m-bromobenzoic acid

glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

N-(2-amino-2-oxoethyl)-3-bromobenzamide

N-(2-amino-2-oxoethyl)-3-bromobenzamide

Conditions
ConditionsYield
Stage #1: glycinamide hydrochloride With triethylamine In dichloromethane for 0.25h;
Stage #2: m-bromobenzoic acid With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide In dichloromethane; ethyl acetate at 20℃; Cooling with ice;
97%
glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

(2R)-2-{[(benzyloxy)carbonyl]amino}-4-tert-butoxy-4-oxobutanoic acid
71449-08-6

(2R)-2-{[(benzyloxy)carbonyl]amino}-4-tert-butoxy-4-oxobutanoic acid

D-(benzyloxycarbonyl)-β-tert-butylaspartylglycinamide
146349-33-9

D-(benzyloxycarbonyl)-β-tert-butylaspartylglycinamide

Conditions
ConditionsYield
With 1-hydroxy-pyrrolidine-2,5-dione; triethylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide a) 4 deg C, 3 h, b) RT, 4 h;96.6%
glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

(1H-indol-3-ylcarbonyl)-Asp-Phe-NMeBzl
131949-12-7

(1H-indol-3-ylcarbonyl)-Asp-Phe-NMeBzl

(1H-indol-3-ylcarbonyl)-Asp(Gly-NH2)-Phe-NMeBzl

(1H-indol-3-ylcarbonyl)-Asp(Gly-NH2)-Phe-NMeBzl

Conditions
ConditionsYield
With benzotriazol-1-ol In N,N-dimethyl-formamide 1.) 0 deg C, 1 h, 2.) RT, 3 h;96%
3,5,5-trimethyl hexanal
5435-64-3

3,5,5-trimethyl hexanal

glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

(+/-)-2-(2,4,4-trimethylpentyl)imidazolidin-4-one
1378479-17-4

(+/-)-2-(2,4,4-trimethylpentyl)imidazolidin-4-one

Conditions
ConditionsYield
With triethylamine In methanol for 18h; Inert atmosphere; Reflux;96%
2,2’-difluoro-3’-methoxy-[1,1‘-biphenyl]-3-carboxylic acid

2,2’-difluoro-3’-methoxy-[1,1‘-biphenyl]-3-carboxylic acid

glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

N-(2-amino-2-oxoethyl)-2,2’-difluoro-3’-methoxy-[1,1‘-biphenyl]-3-carboxamide

N-(2-amino-2-oxoethyl)-2,2’-difluoro-3’-methoxy-[1,1‘-biphenyl]-3-carboxamide

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;96%
4-Aminopent-3-en-2-one
1118-66-7

4-Aminopent-3-en-2-one

glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

N-(1-methyl-3-oxo-1-butenyl)glycinamide
131474-82-3

N-(1-methyl-3-oxo-1-butenyl)glycinamide

Conditions
ConditionsYield
In methanol for 3h; Heating;95%
3-phenylbenzoic acid
716-76-7

3-phenylbenzoic acid

glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

N-(2-amino-2-oxoethyl)-[1,1‘-biphenyl]-3-carboxamide

N-(2-amino-2-oxoethyl)-[1,1‘-biphenyl]-3-carboxamide

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane95%
glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

glycine
56-40-6

glycine

Conditions
ConditionsYield
Stage #1: glycinamide hydrochloride With sodium hydroxide In water
Stage #2: In water at 130℃; for 1h; Reagent/catalyst;
94.5%
6-boronopyrazolo[1,5-a]pyrimidine-3-carboxylic acid
1065083-05-7

6-boronopyrazolo[1,5-a]pyrimidine-3-carboxylic acid

glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

(3-{[(2-amino-2-oxoethyl)amino]carbonyl}pyrazolo[1,5-a]pyrimidin-6-yl)boronic acid
1065083-09-1

(3-{[(2-amino-2-oxoethyl)amino]carbonyl}pyrazolo[1,5-a]pyrimidin-6-yl)boronic acid

Conditions
ConditionsYield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N,N-dimethyl-formamide at 20℃; for 1.5h;94%
ethyl 3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzoate
1207970-84-0

ethyl 3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzoate

glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

N-(2-amino-2-oxoethyl)-3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzamide
1207965-12-5

N-(2-amino-2-oxoethyl)-3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzamide

Conditions
ConditionsYield
Stage #1: ethyl 3-{2-[3-(trifluoromethyl)benzyl]-1-benzothiophen-7-yl}benzoate With water; sodium hydroxide In tetrahydrofuran; ethanol at 60℃; for 0.5h;
Stage #2: With hydrogenchloride In tetrahydrofuran; ethanol; water
Stage #3: glycinamide hydrochloride With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 2h;
94%
2-(3,5-dichloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester
1178896-02-0, 1251932-92-9

2-(3,5-dichloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester

glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

2-(3-(2-amino-2-oxoethylamino)-5-chloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester
1251933-09-1

2-(3-(2-amino-2-oxoethylamino)-5-chloro-6-methyl-2-oxopyrazin-1(2H)-yl)-2-phenylacetic acid methyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In acetonitrile at 100℃; for 3h; Microwave irradiation; Sealed vial;94%
2-methylundecanal
110-41-8

2-methylundecanal

glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

(+/-)-2-(undecan-2-yl)imidazolidin-4-one
1378479-35-6

(+/-)-2-(undecan-2-yl)imidazolidin-4-one

Conditions
ConditionsYield
With triethylamine In methanol for 18h; Inert atmosphere; Reflux;94%
glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

Fmoc-Asp(tBu)-Glu(tBu)-Val-Asp(tBu)-OH

Fmoc-Asp(tBu)-Glu(tBu)-Val-Asp(tBu)-OH

C47H66N6O13

C47H66N6O13

Conditions
ConditionsYield
Stage #1: Fmoc-Asp(tBu)-Glu(tBu)-Val-Asp(tBu)-OH With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 20℃; for 0.75h;
Stage #2: glycinamide hydrochloride In N,N-dimethyl-formamide at 20℃; for 3h;
94%
glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

5-amino-4-hexen-3-one
114042-88-5

5-amino-4-hexen-3-one

N-(1-methyl-3-oxo-1-pentenyl)glycinamide
131474-85-6

N-(1-methyl-3-oxo-1-pentenyl)glycinamide

Conditions
ConditionsYield
In methanol for 3h; Heating;93%
ethyl 3-(5-chloro-2-methoxyphenyl)-3-oxopropanoate
104029-20-1

ethyl 3-(5-chloro-2-methoxyphenyl)-3-oxopropanoate

glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

(Z)-ethyl 3-((2-amino-2-oxoethyl)amino)-3-(5-chloro-2-methoxyphenyl)acrylate
1435472-76-6

(Z)-ethyl 3-((2-amino-2-oxoethyl)amino)-3-(5-chloro-2-methoxyphenyl)acrylate

Conditions
ConditionsYield
Stage #1: glycinamide hydrochloride With sodium methylate In methanol at 65℃; for 1h;
Stage #2: ethyl 3-(5-chloro-2-methoxyphenyl)-3-oxopropanoate With acetic acid at 50℃; for 16h;
93%
Stage #1: glycinamide hydrochloride With sodium methylate In methanol at 65℃; for 1h;
Stage #2: ethyl 3-(5-chloro-2-methoxyphenyl)-3-oxopropanoate With acetic acid In methanol at 50℃; for 16h; Reflux;
339.4 g
glycinamide hydrochloride
1668-10-6

glycinamide hydrochloride

(Z)-3-amino-1-(p-tolyl)but-2-en-1-one
131474-81-2

(Z)-3-amino-1-(p-tolyl)but-2-en-1-one

N-(1-methyl-3-oxo-3-p-tolyl-1-propenyl)glycinamide
131474-97-0

N-(1-methyl-3-oxo-3-p-tolyl-1-propenyl)glycinamide

Conditions
ConditionsYield
In methanol for 6h; Heating;92%

1668-10-6Relevant articles and documents

Cobalt, nickel and copper complexes with glycinamide: Structural insights and magnetic properties

Vu?ak, Darko,Smre?ki, Neven,Prugove?ki, Biserka,Dilovi?, Ivica,Kirasi?, Inka,?ili?, Dijana,Muratovi?, Senada,Matkovi?-?alogovi?, Dubravka

, p. 21637 - 21645 (2019)

Ten new compounds of Co, Ni and Cu with glycinamide (HL = glycinamide): [Co(H2O)2(HL)2]Cl2 (1a), [Co(H2O)2(HL)2]Br1.06Cl0.94 (1b), [Co(H2O)2(HL)2]I2 (1c), [Ni(H2O)2(HL)2]Cl2 (2a), [Ni(H2O)2(HL)2]Br0.94Cl1.06 (2b), [Ni(H2O)2(HL)2]I2 (low and room temperature polymorph, 2cLT and 2cRT), [CuCl2(HL)2] (3a), [CuBr1.3Cl0.7(HL)2] (3b) and {[Cu(HL)2]2[Cu2I6]}n (3c), as well as glycinamide hydroiodide (H2LI) and a new polymorph of glycinamide hydrochloride (β-H2LCl) were prepared and characterized by single-crystal X-ray diffraction, infrared spectroscopy, thermal analysis (TG/DTA) and ESR spectroscopy. 1a, 1b, 2a and 2b are isostructural, as well as 1c and 2cRT, while the Cu compounds (3a-c) have entirely different molecular structures. All investigated compounds are mononuclear with exception of the 1D coordination polymer 3c. Compound 3c contains copper ions in the mixed oxidation state Cu(i) and Cu(ii) with interesting magnetic properties. Paramagnetic behaviour was found in 1a, 1b, 3a and 3b. Temperature induced polymorphic transformation was observed in 2c. Compounds 1a and 3a showed moderate antiproliferative activity and selectivity toward the human breast tumor cell line MCF-7.

Fluorobenzamides and uses thereof

-

, (2008/06/13)

The invention relates to fluorobenzamide derivatives of the formula wherein R1, R2, R3 R4, R5, R6 and R7 are as defined herein. =, The compounds of the invention are selective monoamine oxidase B inhibitors and therefore they are suitable for the treatment of diseases mediated by monoamine oxidase B, such as Alzheimer's disease or senile dementia.

Synthesis of α-amino dithioesters and endothiodipeptides

Hartke, Klaus,Barrmeyer, Stephan

, p. 251 - 256 (2007/10/03)

The α-amino ester hydrochlorides (1) are converted into N-protected α-amino amides (3), α-amino thioamides (4) and α-amino dithiomethylesters (5). Condensation of 5 with the alkali salts of α-amino acids gives rise to the endothiodipeptide alkali salts (7). Johann Ambrosius Barth 1996.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1668-10-6