1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoyl-S-methylisothiocarbamoyl)amino>pyrazole-4-carboxamide

Base Information

• Chemical Name: 1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoyl-S-methylisothiocarbamoyl)amino>pyrazole-4-carboxamide
• CAS No.: 129797-26-8
• Molecular Formula: C₂₁H₂₅N₅O₆S
• Molecular Weight: 475.525

Synonyms:1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoyl-S-methylisothiocarbamoyl)amino>pyrazole-4-carboxamide

Chemical Property of 1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoyl-S-methylisothiocarbamoyl)amino>pyrazole-4-carboxamide

Chemical Property:

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Technology Process of 1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoyl-S-methylisothiocarbamoyl)amino>pyrazole-4-carboxamide

There total 3 articles about 1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoyl-S-methylisothiocarbamoyl)amino>pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoylthiocarbamoyl)amino>pyrazole-4-carboxamide (129797-24-6) + methyl iodide (74-88-4) → 1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoyl-S-methylisothiocarbamoyl)amino>pyrazole-4-carboxamide (129797-26-8)

Guidance literature:

With sodium hydroxide; In methanol; for 2.5h; Ambient temperature;

DOI:10.1002/jhet.5570270357

Reference yield:

Benzoyl isothiocyanate (532-55-8) → 1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoyl-S-methylisothiocarbamoyl)amino>pyrazole-4-carboxamide (129797-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / acetone / 6 h / Heating

2: 96 percent / 0.1 N aq.NaOH / methanol / 2.5 h / Ambient temperature

With sodium hydroxide; In methanol; acetone;

DOI:10.1002/jhet.5570270357

Reference yield:

5-amino-1-(2',3'O-isopropylidene-β-D-ribofuranosyl)pyrazole-4-carboxamide (53762-14-4) → 1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoyl-S-methylisothiocarbamoyl)amino>pyrazole-4-carboxamide (129797-26-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / acetone / 6 h / Heating

2: 96 percent / 0.1 N aq.NaOH / methanol / 2.5 h / Ambient temperature

With sodium hydroxide; In methanol; acetone;

DOI:10.1002/jhet.5570270357

upstream raw materials:

1-(2,3-O-isopropylidene-β-D-ribofuranosyl)-5-<(N'-benzoylthiocarbamoyl)amino>pyrazole-4-carboxamide

methyl iodide

Benzoyl isothiocyanate

5-amino-1-(2',3'O-isopropylidene-β-D-ribofuranosyl)pyrazole-4-carboxamide

Downstream raw materials:

6-amino-1-(β-D-ribofuranosyl)-1H-pyrazolo<3,4-d>pyrimidin-4(5H)-one

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