dicyclopropylmethyl-[9-(4-difluoromethoxy-2-fluoro-phenyl)-2,8-dimethyl-9H-purin-6-yl]-amine

Base Information

Chemical Name:dicyclopropylmethyl-[9-(4-difluoromethoxy-2-fluoro-phenyl)-2,8-dimethyl-9H-purin-6-yl]-amine
CAS No.:1198109-37-3
Molecular Formula:C₂₁H₂₂F₃N₅O
Molecular Weight:417.434
Hs Code.:

Synonyms:dicyclopropylmethyl-[9-(4-difluoromethoxy-2-fluoro-phenyl)-2,8-dimethyl-9H-purin-6-yl]-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dicyclopropylmethyl-[9-(4-difluoromethoxy-2-fluoro-phenyl)-2,8-dimethyl-9H-purin-6-yl]-amine

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Technology Process of dicyclopropylmethyl-[9-(4-difluoromethoxy-2-fluoro-phenyl)-2,8-dimethyl-9H-purin-6-yl]-amine

There total 8 articles about dicyclopropylmethyl-[9-(4-difluoromethoxy-2-fluoro-phenyl)-2,8-dimethyl-9H-purin-6-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1198109-69-1
4-[6-(dicyclopropylmethyl-amino)-2,8-dimethyl-purin-9-yl]-3-fluoro-phenol

: 1895-39-2
sodium chlorodifluoroacetate

: 1198109-37-3
dicyclopropylmethyl-[9-(4-difluoromethoxy-2-fluoro-phenyl)-2,8-dimethyl-9H-purin-6-yl]-amine

Guidance literature:: With caesium carbonate; In water; N,N-dimethyl-formamide; at 100 ℃; for 18h; Inert atmosphere;

Reference yield:

: 394-41-2
3-fluoro-4-nitrophenol

: 1198109-37-3
dicyclopropylmethyl-[9-(4-difluoromethoxy-2-fluoro-phenyl)-2,8-dimethyl-9H-purin-6-yl]-amine

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 20 °C / 2068.65 Torr

2: hydrogenchloride / ethanol; water / 6 h / 85 °C / Inert atmosphere

3: triethylamine / acetonitrile / 19 h / 20 - 74 °C / Inert atmosphere

4: triethylamine / butan-1-ol / 18 h / Reflux; Inert atmosphere

5: caesium carbonate / water; N,N-dimethyl-formamide / 18 h / 100 °C / Inert atmosphere

With hydrogenchloride; hydrogen; caesium carbonate; triethylamine; palladium 10% on activated carbon; In ethanol; water; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;

Reference yield:

: 1003865-65-3
4-(difluoromethoxy)-2-fluoro-aniline

: 1198109-37-3
dicyclopropylmethyl-[9-(4-difluoromethoxy-2-fluoro-phenyl)-2,8-dimethyl-9H-purin-6-yl]-amine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / ethanol / 24 h / 20 - 80 °C

2: triethylamine / acetonitrile / 21 h / 75 °C

3: acetonitrile / 0.5 h / 160 °C / Microwave irradiation

With hydrogenchloride; triethylamine; In ethanol; acetonitrile;
DOI:10.1016/j.bmcl.2011.08.040