4-[6-(dicyclopropylmethyl-amino)-2,8-dimethyl-purin-9-yl]-3-fluoro-phenol

Base Information

Chemical Name:4-[6-(dicyclopropylmethyl-amino)-2,8-dimethyl-purin-9-yl]-3-fluoro-phenol
CAS No.:1198109-69-1
Molecular Formula:C₂₀H₂₂FN₅O
Molecular Weight:367.426
Hs Code.:

Synonyms:4-[6-(dicyclopropylmethyl-amino)-2,8-dimethyl-purin-9-yl]-3-fluoro-phenol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[6-(dicyclopropylmethyl-amino)-2,8-dimethyl-purin-9-yl]-3-fluoro-phenol

Chemical Property:

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Technology Process of 4-[6-(dicyclopropylmethyl-amino)-2,8-dimethyl-purin-9-yl]-3-fluoro-phenol

There total 4 articles about 4-[6-(dicyclopropylmethyl-amino)-2,8-dimethyl-purin-9-yl]-3-fluoro-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1198109-68-0
4-(6-chloro-2,8-dimethyl-purin-9-yl)-3-fluoro-phenol

: 13375-29-6
dicyclopropylmethylamine

: 1198109-69-1
4-[6-(dicyclopropylmethyl-amino)-2,8-dimethyl-purin-9-yl]-3-fluoro-phenol

Guidance literature:: With triethylamine; In butan-1-ol; for 18h; Reflux; Inert atmosphere;

Reference yield:

: 394-41-2
3-fluoro-4-nitrophenol

: 1198109-69-1
4-[6-(dicyclopropylmethyl-amino)-2,8-dimethyl-purin-9-yl]-3-fluoro-phenol

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 20 °C / 2068.65 Torr

2: hydrogenchloride / ethanol; water / 6 h / 85 °C / Inert atmosphere

3: triethylamine / acetonitrile / 19 h / 20 - 74 °C / Inert atmosphere

4: triethylamine / butan-1-ol / 18 h / Reflux; Inert atmosphere

With hydrogenchloride; hydrogen; triethylamine; palladium 10% on activated carbon; In ethanol; water; acetonitrile; butan-1-ol;

Reference yield:

: 1198109-67-9
4-(5-amino-6-chloro-2-methyl-pyrimidin-4-ylamino)-3-fluoro-phenol

: 1198109-69-1
4-[6-(dicyclopropylmethyl-amino)-2,8-dimethyl-purin-9-yl]-3-fluoro-phenol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / acetonitrile / 19 h / 20 - 74 °C / Inert atmosphere

2: triethylamine / butan-1-ol / 18 h / Reflux; Inert atmosphere

With triethylamine; In acetonitrile; butan-1-ol;