5-tert-butyl-1H-pyrazole-3-carboxylic acid (1-chloromethyl-2-phenyl-ethyl)-amide

Base Information

• Chemical Name: 5-tert-butyl-1H-pyrazole-3-carboxylic acid (1-chloromethyl-2-phenyl-ethyl)-amide
• CAS No.: 226998-63-6
• Molecular Formula: C₁₇H₂₂ClN₃O
• Molecular Weight: 319.834

Synonyms:5-tert-butyl-1H-pyrazole-3-carboxylic acid (1-chloromethyl-2-phenyl-ethyl)-amide

Chemical Property of 5-tert-butyl-1H-pyrazole-3-carboxylic acid (1-chloromethyl-2-phenyl-ethyl)-amide

Chemical Property:

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Technology Process of 5-tert-butyl-1H-pyrazole-3-carboxylic acid (1-chloromethyl-2-phenyl-ethyl)-amide

There total 3 articles about 5-tert-butyl-1H-pyrazole-3-carboxylic acid (1-chloromethyl-2-phenyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

5-tert-butyl-1H-pyrazole-3-carboxylic acid (1-hydroxymethyl-2-phenyl-ethyl)-amide (226998-51-2) → 5-tert-butyl-1H-pyrazole-3-carboxylic acid (1-chloromethyl-2-phenyl-ethyl)-amide (226998-63-6)

Guidance literature:

With thionyl chloride; In 1,2-dichloro-ethane; at 40 ℃;

DOI:10.1016/S0040-4039(99)00582-1

Reference yield:

3,3-dimethyl-butan-2-one (75-97-8) → 5-tert-butyl-1H-pyrazole-3-carboxylic acid (1-chloromethyl-2-phenyl-ethyl)-amide (226998-63-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / NaH / tetrahydrofuran / Heating

2: 49 percent / hydrazine monohydrate / ethanol / 80 °C

3: 99 percent / SOCl₂ / 1,2-dichloro-ethane / 40 °C

With thionyl chloride; sodium hydride; hydrazine hydrate; In tetrahydrofuran; ethanol; 1,2-dichloro-ethane;

DOI:10.1016/S0040-4039(99)00582-1

Reference yield:

2-hydroxy-5,5-dimethyl-4-oxo-hex-2-enoic acid methyl ester (39847-92-2) → 5-tert-butyl-1H-pyrazole-3-carboxylic acid (1-chloromethyl-2-phenyl-ethyl)-amide (226998-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 49 percent / hydrazine monohydrate / ethanol / 80 °C

2: 99 percent / SOCl₂ / 1,2-dichloro-ethane / 40 °C

With thionyl chloride; hydrazine hydrate; In ethanol; 1,2-dichloro-ethane;

DOI:10.1016/S0040-4039(99)00582-1

upstream raw materials:

5-tert-butyl-1H-pyrazole-3-carboxylic acid (1-hydroxymethyl-2-phenyl-ethyl)-amide

3,3-dimethyl-butan-2-one

2-hydroxy-5,5-dimethyl-4-oxo-hex-2-enoic acid methyl ester

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