4-Methoxy-1-[(1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-3-triisopropylsilanyl-pyridinium; chloride

Base Information

• Chemical Name: 4-Methoxy-1-[(1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-3-triisopropylsilanyl-pyridinium; chloride
• CAS No.: 144375-66-6
• Molecular Formula: C₃₂H₅₀NO₃Si*Cl
• Molecular Weight: 560.292
• Mol file: 144375-66-6.mol

Synonyms:4-Methoxy-1-[(1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-3-triisopropylsilanyl-pyridinium; chloride

Chemical Property of 4-Methoxy-1-[(1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-3-triisopropylsilanyl-pyridinium; chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Methoxy-1-[(1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-3-triisopropylsilanyl-pyridinium; chloride

There total 3 articles about 4-Methoxy-1-[(1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-3-triisopropylsilanyl-pyridinium; chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-3-(trisopropylsilyl)pyridine (126378-42-5) + (1R,2S,5R)-(-)-8-phenylmenthyl chloroformate (126378-43-6) → 4-Methoxy-1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-3-triisopropylsilanyl-pyridinium; chloride (144375-66-6)

Guidance literature:

DOI:10.1021/jo00026a004 DOI:10.1021/jo00048a003

Reference yield:

4-methoxy-3-(trisopropylsilyl)pyridine (126378-42-5) + (-)-8-phenylmenthol chloroformate (126378-43-6) → 4-Methoxy-1-[(1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-3-triisopropylsilanyl-pyridinium; chloride (144375-66-6)

Guidance literature:

DOI:10.1021/jo00296a006

Reference yield:

4-methoxy-3-(trisopropylsilyl)pyridine (126378-42-5) + (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl chloroformate (161693-64-7) → 4-Methoxy-1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-3-triisopropylsilanyl-pyridinium; chloride (144375-66-6)

Guidance literature:

DOI:10.1021/jo00071a005

upstream raw materials:

4-methoxy-3-(trisopropylsilyl)pyridine

(-)-8-phenylmenthol chloroformate

(1R,2S,5R)-(-)-8-phenylmenthyl chloroformate

(1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl chloroformate

Downstream raw materials:

(S)-2-Isobutyl-4-oxo-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

(R)-2-Isobutyl-4-oxo-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

(R)-4-Oxo-2-o-tolyl-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

(S)-4-Oxo-2-o-tolyl-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R,5S)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester