Carbonochloridic acid, (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester

Base Information

• Chemical Name: Carbonochloridic acid, (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester
• CAS No.: 161693-64-7
• Molecular Formula: C16H21ClO2
• Molecular Weight: 280.795
• Mol file: 161693-64-7.mol

Synonyms:

Chemical Property of Carbonochloridic acid, (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbonochloridic acid, (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester

There total 1 articles about Carbonochloridic acid, (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

phosgene (75-44-5) + (1S,2R)-(+)-trans-2-(1-methyl-1-phenylethyl)cyclohexanol (109527-45-9) → (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl chloroformate (161693-64-7)

Guidance literature:

With quinoline; In toluene; at 20 ℃;

DOI:10.1016/j.tetlet.2003.12.080

Reference yield: 90.0%

oxisoindole (480-91-1) + (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl chloroformate (161693-64-7) → N-[(((1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl)oxy)carbonyl]-2,3-dihydro-isoindol-1-one (837361-44-1)

Guidance literature:

With n-butyllithium;

DOI:10.1021/ol047824w

Reference yield: 89.0%

4-methoxybenzylmagnesium chloride (38769-92-5) + 4-methoxy-3-(trisopropylsilyl)pyridine (126378-42-5) + (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl chloroformate (161693-64-7) → (2S)-1-[((1S,2R)-trans-2-(α-cumyl)cyclohexyloxy)carbonyl]-2-(4-methoxy)benzyl-5-(triisopropylsilyl)-2,3-dihydro-4-pyridone (244183-00-4) + (2R)-1-[((1S,2R)-trans-2-(α-cumyl)cyclohexyloxy)carbonyl]-2-(4-methoxy)benzyl-5-(triisopropylsilyl)-2,3-dihydro-4-pyridone

Guidance literature:

4-methoxy-3-(trisopropylsilyl)pyridine; (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl chloroformate; In toluene; at -42 ℃;

4-methoxybenzylmagnesium chloride; In toluene; at -78 ℃;

With hydrogenchloride; In toluene; at 20 ℃; Further stages.;

DOI:10.1021/ol990738p

upstream raw materials:

phosgene

(1S,2R)-(+)-trans-2-(1-methyl-1-phenylethyl)cyclohexanol

Downstream raw materials:

4-Methoxy-1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-3-triisopropylsilanyl-pyridinium; chloride

N-[(1S,2R)-(2-(1-methyl-1-phenylethyl)cyclohexyloxy)carbonyl]-2-(3,4-dimethoxyphenyl)ethylamine

(R)-4-Oxo-2-((1E,3E)-4-phenyl-buta-1,3-dienyl)-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R)-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

(R)-4-Oxo-2-((Z)-propenyl)-5-triisopropylsilanyl-3,4-dihydro-2H-pyridine-1-carboxylic acid (1S,2R)-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester

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