Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Base Information

• Chemical Name: Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester
• CAS No.: 80667-97-6
• Molecular Formula: C₁₉H₂₂N₂O₉S
• Molecular Weight: 454.458
• Mol file: 80667-97-6.mol

Synonyms:Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Chemical Property of Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

There total 8 articles about Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.7%

4-Oxo-pentanoic acid (2R,3S,5R)-2-(2-benzenesulfonyl-ethoxycarbonyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (80667-95-4) → Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (80667-97-6)

Guidance literature:

With hydrazine; In pyridine; acetic acid; at 20 ℃;

DOI:10.1016/S0040-4039(01)81988-2

Reference yield: 96.0%

Carbonic acid (2R,3S,5R)-2-(2-benzenesulfonyl-ethoxycarbonyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-trimethylsilanyl-ethyl ester (80667-94-3) → Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (80667-97-6)

Guidance literature:

With zinc dibromide; In nitromethane; at 20 ℃;

DOI:10.1016/S0040-4039(01)81988-2

Reference yield: 92.0%

Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester (80680-59-7) → Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester (80667-97-6)

Guidance literature:

acid;

DOI:10.1016/S0040-4039(01)81988-2

upstream raw materials:

Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester

4-Oxo-pentanoic acid (2R,3S,5R)-2-(2-benzenesulfonyl-ethoxycarbonyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

Carbonic acid (2R,3S,5R)-2-(2-benzenesulfonyl-ethoxycarbonyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 2-trimethylsilanyl-ethyl ester

2-Phenylsulfonylethylchloroformate (PSEC)

Downstream raw materials:

3'-O-benzoylthymidine

C₅₄H₅₀ClN₄O₁₇PS

C₄₅H₄₂ClN₄O₁₃P

C₃₅H₃₈ClN₄O₁₆PS