Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester

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Chemical Name:Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester
CAS No.:80680-59-7
Molecular Formula:C₂₄H₃₀N₂O₁₀S
Molecular Weight:538.576
Hs Code.:

Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester

Synonyms:Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester

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Chemical Property of Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester

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Technology Process of Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester

There total 1 articles about Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.6%

: 74063-48-2
2-Phenylsulfonylethylchloroformate (PSEC)

: 76541-04-3
3'-O-(tetrahydropyranyl)thymidine

: 80680-59-7
Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: In pyridine; at 20 ℃; for 0.5h;
DOI:10.1016/S0040-4039(01)81988-2

Reference yield: 92.0%

: 80680-59-7
Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester

: 80667-97-6
Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Guidance literature:: acid;
DOI:10.1016/S0040-4039(01)81988-2

Reference yield:

: 80680-59-7
Carbonic acid 2-benzenesulfonyl-ethyl ester (2R,3S,5R)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-2-ylmethyl ester

: 17331-53-2
3'-O-benzoylthymidine

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / acid

2: Benzoylation

3: 84.7 percent / Triethylamine / pyridine / 20 h / 20 °C

With triethylamine; In pyridine;
DOI:10.1016/S0040-4039(01)81988-2