4-[(benzyloxy)carbonyl]-2-piperazinecarboxylic acid copper

Base Information

• Chemical Name: 4-[(benzyloxy)carbonyl]-2-piperazinecarboxylic acid copper
• CAS No.: 67889-51-4
• Molecular Formula: C₂₆H₃₀CuN₄O₈
• Molecular Weight: 590.092
• Mol file: 67889-51-4.mol

Synonyms:4-[(benzyloxy)carbonyl]-2-piperazinecarboxylic acid copper

Chemical Property of 4-[(benzyloxy)carbonyl]-2-piperazinecarboxylic acid copper

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-[(benzyloxy)carbonyl]-2-piperazinecarboxylic acid copper

There total 1 articles about 4-[(benzyloxy)carbonyl]-2-piperazinecarboxylic acid copper which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

copper(I) sulfate + piperazine-2-carboxylic acid dihydrochloride (3022-15-9,126330-90-3,133525-05-0,135841-26-8) + benzyl chloroformate (501-53-1,94274-21-2) → 4-[(benzyloxy)carbonyl]-2-piperazinecarboxylic acid copper (67889-51-4)

Guidance literature:

With sodium hydroxide; sodium carbonate; In 1,4-dioxane; water; at 5 - 20 ℃; for 24h;

Reference yield:

4-[(benzyloxy)carbonyl]-2-piperazinecarboxylic acid copper (67889-51-4) + ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → 4-carbobenzyloxy-1-(2-nitrophenyl)-piperazine-2-carboxylic acid (64173-00-8)

Guidance literature:

4-[(benzyloxy)carbonyl]-2-piperazinecarboxylic acid copper; With ethylenediaminetetraacetic acid; In water; at 80 ℃; for 3h;

ortho-nitrofluorobenzene; With triethylamine; In dimethyl sulfoxide; at 60 ℃; for 48h;

With hydrogenchloride; water; In dimethyl sulfoxide; pH=3;

Reference yield:

4-[(benzyloxy)carbonyl]-2-piperazinecarboxylic acid copper (67889-51-4) → benzyl 8-bromo-5-oxo-1,2,4,4a,5,6-hexahydro-3H-pyrazino-[1,2-a]quinoxaline-3-carboxylate (444161-48-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethylenediaminetetraacetic acid / water / 3 h / 80 °C

1.2: 48 h / 60 °C

1.3: pH 3

2.1: iron; acetic acid / 3 h / 60 °C

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1.5 h / 20 °C

With N-Bromosuccinimide; ethylenediaminetetraacetic acid; iron; acetic acid; In water; N,N-dimethyl-formamide;

upstream raw materials:

piperazine-2-carboxylic acid dihydrochloride

benzyl chloroformate

Downstream raw materials:

4-carbobenzyloxy-1-(2-nitrophenyl)-piperazine-2-carboxylic acid

benzyl 8-bromo-5-oxo-1,2,4,4a,5,6-hexahydro-3H-pyrazino-[1,2-a]quinoxaline-3-carboxylate

3-benzyloxycarbonyl-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-one

Refernces