3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridine-3-ylmethyl)-1H-1,2,3-benzotriazol-6-yl]oxy}benzonitrile

Base Information

• Chemical Name: 3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridine-3-ylmethyl)-1H-1,2,3-benzotriazol-6-yl]oxy}benzonitrile
• CAS No.: 1345336-38-0
• Molecular Formula: C₂₀H₁₁Cl₂N₇O
• Molecular Weight: 436.26
• Mol file: 1345336-38-0.mol

Synonyms:3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridine-3-ylmethyl)-1H-1,2,3-benzotriazol-6-yl]oxy}benzonitrile

Chemical Property of 3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridine-3-ylmethyl)-1H-1,2,3-benzotriazol-6-yl]oxy}benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridine-3-ylmethyl)-1H-1,2,3-benzotriazol-6-yl]oxy}benzonitrile

There total 10 articles about 3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridine-3-ylmethyl)-1H-1,2,3-benzotriazol-6-yl]oxy}benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-{4-amino-2-chloro-5-[(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)amino]phenoxy}-5-chlorobenzonitrile (1345336-45-9) → 3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridine-3-ylmethyl)-1H-1,2,3-benzotriazol-6-yl]oxy}benzonitrile (1345336-38-0)

Guidance literature:

With acetic acid; sodium nitrite; In water; for 0.166667h; Inert atmosphere;

DOI:10.1021/jm2010173

Reference yield:

C24H20BrCl2N5O5 → 3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridine-3-ylmethyl)-1H-1,2,3-benzotriazol-6-yl]oxy}benzonitrile (1345336-38-0)

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid / 0.5 h / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 95 °C / Inert atmosphere

3: tin(ll) chloride / water / 1 h / Reflux; Inert atmosphere

4: acetic acid; sodium nitrite / water / 0.17 h / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid; trifluoroacetic acid; tin(ll) chloride; sodium nitrite; In water; N,N-dimethyl-formamide;

DOI:10.1021/jm2010173

Reference yield:

3-chloro-5-{2-chloro-4-nitro-5-[(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)amino]phenoxy}benzonitrile (1345337-31-6) → 3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridine-3-ylmethyl)-1H-1,2,3-benzotriazol-6-yl]oxy}benzonitrile (1345336-38-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tin(ll) chloride / water / 1 h / Reflux; Inert atmosphere

2: acetic acid; sodium nitrite / water / 0.17 h / Inert atmosphere

With acetic acid; tin(ll) chloride; sodium nitrite; In water;

DOI:10.1021/jm2010173

upstream raw materials:

3-chloro-5-{2-chloro-4-nitro-5-[(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)amino]phenoxy}benzonitrile

3-{4-amino-2-chloro-5-[(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)amino]phenoxy}-5-chlorobenzonitrile

4,5-dichloro-N-(methoxybenzyl)-2-nitroaniline

5-(3-bromo-5-chlorophenoxy)-4-chloro-N-(4-methoxybenzyl)-2-nitroaniline