5-(3-bromo-5-chlorophenoxy)-4-chloro-N-(4-methoxybenzyl)-2-nitroaniline

Base Information

• Chemical Name: 5-(3-bromo-5-chlorophenoxy)-4-chloro-N-(4-methoxybenzyl)-2-nitroaniline
• CAS No.: 1345336-85-7
• Molecular Formula: C₂₀H₁₅BrCl₂N₂O₄
• Molecular Weight: 498.16

Synonyms:5-(3-bromo-5-chlorophenoxy)-4-chloro-N-(4-methoxybenzyl)-2-nitroaniline

Chemical Property of 5-(3-bromo-5-chlorophenoxy)-4-chloro-N-(4-methoxybenzyl)-2-nitroaniline

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Technology Process of 5-(3-bromo-5-chlorophenoxy)-4-chloro-N-(4-methoxybenzyl)-2-nitroaniline

There total 2 articles about 5-(3-bromo-5-chlorophenoxy)-4-chloro-N-(4-methoxybenzyl)-2-nitroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4,5-dichloro-N-(methoxybenzyl)-2-nitroaniline (1345336-82-4) + 3-bromo-5-chlorophenol (56962-04-0) → 5-(3-bromo-5-chlorophenoxy)-4-chloro-N-(4-methoxybenzyl)-2-nitroaniline (1345336-85-7)

Guidance literature:

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; Heating; Inert atmosphere;

DOI:10.1021/jm2010173

Reference yield:

1,2-dichloro-4,5-dinitrobenzene (6306-39-4) + 4-methoxy-benzylamine (2393-23-9) → 5-(3-bromo-5-chlorophenoxy)-4-chloro-N-(4-methoxybenzyl)-2-nitroaniline (1345336-85-7)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 1 h / 90 °C / Inert atmosphere

2: potassium carbonate / 1-methyl-pyrrolidin-2-one / Heating; Inert atmosphere

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; toluene;

DOI:10.1021/jm2010173

Reference yield: 100.0%

5-(3-bromo-5-chlorophenoxy)-4-chloro-N-(4-methoxybenzyl)-2-nitroaniline (1345336-85-7) → 5-(3-bromo-5-chlorophenoxy)-4-chloro-2-nitroaniline (1345336-88-0)

Guidance literature:

With trifluoroacetic acid; at 75 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm2010173

upstream raw materials:

4,5-dichloro-N-(methoxybenzyl)-2-nitroaniline

3-bromo-5-chlorophenol

1,2-dichloro-4,5-dinitrobenzene

4-methoxy-benzylamine

Downstream raw materials:

3-chloro-5-{2-chloro-4-nitro-5-[(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)amino]phenoxy}benzonitrile

3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridine-3-ylmethyl)-1H-1,2,3-benzotriazol-6-yl]oxy}benzonitrile

3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridine-3-lmethyl)-1H-benzimidazol-6-yl]oxy}benzonitrile

3-{4-amino-2-chloro-5-[(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)amino]phenoxy}-5-chlorobenzonitrile

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