(R)-methyl 2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzyloxy)hexanoate

Base Information

Chemical Name:(R)-methyl 2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzyloxy)hexanoate
CAS No.:1043890-96-5
Molecular Formula:C₂₃H₂₉F₂NO₃
Molecular Weight:405.485
Hs Code.:

Synonyms:(R)-methyl 2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzyloxy)hexanoate

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Chemical Property of (R)-methyl 2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzyloxy)hexanoate

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Technology Process of (R)-methyl 2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzyloxy)hexanoate

There total 10 articles about (R)-methyl 2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzyloxy)hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 342636-66-2
(4-fluoro-3,5-dimethylphenyl)boronic acid

: 1043890-95-4
(R)-methyl 6-(4-fluoro-3-methylbenzyloxy)-2-aminohexanoate

: 1043890-96-5
(R)-methyl 2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzyloxy)hexanoate

Guidance literature:: With oxygen; copper diacetate; triethylamine; In dichloromethane; at 20 ℃; for 44h; Molecular sieves 4?;

Reference yield:

: 1043453-91-3
6-(4-fluoro-3-methylbenzyloxy)hexanoic acid

: 1043890-96-5
(R)-methyl 2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzyloxy)hexanoate

Guidance literature:: Multi-step reaction with 6 steps

1: pivaloyl chloride; triethylamine; lithium chloride / tetrahydrofuran / -10 - 20 °C

2: 2,4,6-Triisopropylbenzenesulfonyl azide; potassium hexamethylsilazane; acetic acid / tetrahydrofuran; toluene / -78 - 20 °C

3: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 0 °C

4: methanol; dichloromethane

5: 50% Pd-BaSO4; hydrogen / ethyl acetate

6: oxygen; copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve

With 50% Pd-BaSO4; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; dihydrogen peroxide; oxygen; copper diacetate; pivaloyl chloride; potassium hexamethylsilazane; acetic acid; triethylamine; lithium chloride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1016/j.bmcl.2011.02.010

Reference yield:

: 502-44-3,24980-41-4,80137-66-2
hexahydro-2H-oxepin-2-one

: 1043890-96-5
(R)-methyl 2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzyloxy)hexanoate

Guidance literature:: Multi-step reaction with 7 steps

1: potassium hydroxide / toluene / Reflux

2: pivaloyl chloride; triethylamine; lithium chloride / tetrahydrofuran / -10 - 20 °C

3: 2,4,6-Triisopropylbenzenesulfonyl azide; potassium hexamethylsilazane; acetic acid / tetrahydrofuran; toluene / -78 - 20 °C

4: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 0 °C

5: methanol; dichloromethane

6: 50% Pd-BaSO4; hydrogen / ethyl acetate

7: oxygen; copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve

With 50% Pd-BaSO4; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; dihydrogen peroxide; oxygen; copper diacetate; pivaloyl chloride; potassium hexamethylsilazane; acetic acid; triethylamine; lithium chloride; potassium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1016/j.bmcl.2011.02.010