Technology Process of (R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide
There total 11 articles about (R)-2-(4-fluoro-3,5-dimethylphenylamino)-6-(4-fluoro-3-methylbenzyloxy)-N-hydroxyhexanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydroxylamine; potassium cyanide;
In
tetrahydrofuran; methanol; water;
at 20 ℃;
for 15h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: potassium hydroxide / toluene / Reflux
2: pivaloyl chloride; triethylamine; lithium chloride / tetrahydrofuran / -10 - 20 °C
3: 2,4,6-Triisopropylbenzenesulfonyl azide; potassium hexamethylsilazane; acetic acid / tetrahydrofuran; toluene / -78 - 20 °C
4: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 0 °C
5: methanol; dichloromethane
6: 50% Pd-BaSO4; hydrogen / ethyl acetate
7: oxygen; copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve
8: potassium cyanide; hydroxylamine monohydrate / tetrahydrofuran; methanol / 20 °C
With
potassium cyanide; hydroxylamine monohydrate; 50% Pd-BaSO4; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; dihydrogen peroxide; oxygen; copper diacetate; pivaloyl chloride; potassium hexamethylsilazane; acetic acid; triethylamine; lithium chloride; potassium hydroxide; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1016/j.bmcl.2011.02.010
- Guidance literature:
-
Multi-step reaction with 7 steps
1: pivaloyl chloride; triethylamine; lithium chloride / tetrahydrofuran / -10 - 20 °C
2: 2,4,6-Triisopropylbenzenesulfonyl azide; potassium hexamethylsilazane; acetic acid / tetrahydrofuran; toluene / -78 - 20 °C
3: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 0 °C
4: methanol; dichloromethane
5: 50% Pd-BaSO4; hydrogen / ethyl acetate
6: oxygen; copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve
7: potassium cyanide; hydroxylamine monohydrate / tetrahydrofuran; methanol / 20 °C
With
potassium cyanide; hydroxylamine monohydrate; 50% Pd-BaSO4; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; dihydrogen peroxide; oxygen; copper diacetate; pivaloyl chloride; potassium hexamethylsilazane; acetic acid; triethylamine; lithium chloride; lithium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1016/j.bmcl.2011.02.010
