benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(4-methyl-N-(3-(trifluoromethoxy)benzyl)phenylsulfonamido)acetamido)benzoate

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Chemical Name:benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(4-methyl-N-(3-(trifluoromethoxy)benzyl)phenylsulfonamido)acetamido)benzoate
CAS No.:1455005-89-6
Molecular Formula:C₅₁H₄₉F₃N₂O₇S
Molecular Weight:891.02
Hs Code.:

Synonyms:benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(4-methyl-N-(3-(trifluoromethoxy)benzyl)phenylsulfonamido)acetamido)benzoate

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Chemical Property of benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(4-methyl-N-(3-(trifluoromethoxy)benzyl)phenylsulfonamido)acetamido)benzoate

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Technology Process of benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(4-methyl-N-(3-(trifluoromethoxy)benzyl)phenylsulfonamido)acetamido)benzoate

There total 8 articles about benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(4-methyl-N-(3-(trifluoromethoxy)benzyl)phenylsulfonamido)acetamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1331747-40-0
benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-((4-methylphenyl)sulfonamido)acetamido)benzoate

: 1455005-89-6
benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(4-methyl-N-(3-(trifluoromethoxy)benzyl)phenylsulfonamido)acetamido)benzoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm3017255

Reference yield:

: 1241832-99-4
benzyl 4-amino-2-(benzyloxy)benzoate

: 1455005-89-6
benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(4-methyl-N-(3-(trifluoromethoxy)benzyl)phenylsulfonamido)acetamido)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / methanol / 3 h / 45 °C / Molecular sieve; Inert atmosphere

1.2: 45 °C / Inert atmosphere

2.1: dichlorotriphenylphosphorane / chloroform / 0.25 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 110 °C / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With caesium carbonate; acetic acid; dichlorotriphenylphosphorane; In methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm3017255

Reference yield:

: 1241833-16-8
benzyl 2-(benzyloxy)-4-((4-cyclohexylbenzyl)amino)benzoate

: 1455005-89-6
benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(4-methyl-N-(3-(trifluoromethoxy)benzyl)phenylsulfonamido)acetamido)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichlorotriphenylphosphorane / chloroform / 0.25 h / 20 °C / Inert atmosphere

1.2: 0.5 h / 110 °C / Inert atmosphere

2.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With caesium carbonate; dichlorotriphenylphosphorane; In chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm3017255