2-[(1S,2R,3R,6R)-2,6-Dimethyl-3-(2-methyl-[1,3]-dioxolan-2-yl)cyclohexyl]ethanol

Base Information

Chemical Name:2-[(1S,2R,3R,6R)-2,6-Dimethyl-3-(2-methyl-[1,3]-dioxolan-2-yl)cyclohexyl]ethanol
CAS No.:331961-24-1
Molecular Formula:C₁₄H₂₆O₃
Molecular Weight:242.359
Hs Code.:

Synonyms:2-[(1S,2R,3R,6R)-2,6-Dimethyl-3-(2-methyl-[1,3]-dioxolan-2-yl)cyclohexyl]ethanol

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Chemical Property of 2-[(1S,2R,3R,6R)-2,6-Dimethyl-3-(2-methyl-[1,3]-dioxolan-2-yl)cyclohexyl]ethanol

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Technology Process of 2-[(1S,2R,3R,6R)-2,6-Dimethyl-3-(2-methyl-[1,3]-dioxolan-2-yl)cyclohexyl]ethanol

There total 8 articles about 2-[(1S,2R,3R,6R)-2,6-Dimethyl-3-(2-methyl-[1,3]-dioxolan-2-yl)cyclohexyl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 107-21-1
ethylene glycol

: 331961-23-0
1-[(1R,2R,3S,6R)-3-(2-Hydroxyethyl)-2,4-dimethylcyclohexyl]ethanone

: 331961-24-1
2-[(1S,2R,3R,6R)-2,6-Dimethyl-3-(2-methyl-[1,3]-dioxolan-2-yl)cyclohexyl]ethanol

Guidance literature:: With toluene-4-sulfonic acid; trimethyl orthoformate; at 25 ℃; for 2h;
DOI:10.1002/1521-3765(20010119)7:2<520::AID-CHEM520>3.0.CO;2-5

Reference yield:

: 91781-46-3
(6S,5R)-2,6-dimethyl-5-(1-methylethenyl)-2-cyclohexen-1-one

: 331961-24-1
2-[(1S,2R,3R,6R)-2,6-Dimethyl-3-(2-methyl-[1,3]-dioxolan-2-yl)cyclohexyl]ethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 80 percent / aq. NaHCO₃; sodium dithionite / Adogen 464 / toluene / 2 h / Heating

2.1: EtMgBr / toluene; tetrahydrofuran / 0 - 60 °C

2.2: toluene; tetrahydrofuran / 2 h / Heating

2.3: 44 percent / aq. H₂SO₄ / tetrahydrofuran / 10 h

3.1: Mg; methanol

4.1: 97 percent / LiAlH₄ / tetrahydrofuran / 3 h / 25 °C

5.1: O₃ / CH₂Cl₂; methanol / -40 °C

5.2: 89 percent / dimethylsulfide / CH₂Cl₂; methanol / 25 °C

6.1: 83 percent / trimethylorthoformate; p-TsOH / 2 h / 25 °C

With methanol; lithium aluminium tetrahydride; sodium dithionite; ethylmagnesium bromide; sodium hydrogencarbonate; toluene-4-sulfonic acid; ozone; magnesium; trimethyl orthoformate; adogen 464; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1002/1521-3765(20010119)7:2<520::AID-CHEM520>3.0.CO;2-5

Reference yield:

: 331961-14-9
(2S,3R,6R)-2,6-dimethyl-3-(prop-1-en-2-yl)cyclohexan-1-one

: 331961-24-1
2-[(1S,2R,3R,6R)-2,6-Dimethyl-3-(2-methyl-[1,3]-dioxolan-2-yl)cyclohexyl]ethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: EtMgBr / toluene; tetrahydrofuran / 0 - 60 °C

1.2: toluene; tetrahydrofuran / 2 h / Heating

1.3: 44 percent / aq. H₂SO₄ / tetrahydrofuran / 10 h

2.1: Mg; methanol

3.1: 97 percent / LiAlH₄ / tetrahydrofuran / 3 h / 25 °C

4.1: O₃ / CH₂Cl₂; methanol / -40 °C

4.2: 89 percent / dimethylsulfide / CH₂Cl₂; methanol / 25 °C

5.1: 83 percent / trimethylorthoformate; p-TsOH / 2 h / 25 °C

With methanol; lithium aluminium tetrahydride; ethylmagnesium bromide; toluene-4-sulfonic acid; ozone; magnesium; trimethyl orthoformate; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1002/1521-3765(20010119)7:2<520::AID-CHEM520>3.0.CO;2-5