methyl 3-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}propanate

Base Information

Chemical Name:methyl 3-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}propanate
CAS No.:401518-65-8
Molecular Formula:C₂₂H₃₀N₂O₄
Molecular Weight:386.491
Hs Code.:

Synonyms:methyl 3-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}propanate

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Chemical Property of methyl 3-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}propanate

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Technology Process of methyl 3-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}propanate

There total 1 articles about methyl 3-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}propanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidine-4-carbonitrile hydrochloride

: 401518-65-8
methyl 3-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}propanate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 45 ℃; for 24h;
DOI:10.1016/j.bmc.2004.07.040

Reference yield: 50.0%

: 401518-65-8
methyl 3-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}propanate

: 401518-69-2
3-(4-(3-cyclopentyloxy-4-methoxyphenyl)-4-cyanopiperidin-1-yl)propanoic acid

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 3.5h;
DOI:10.1016/j.bmc.2004.07.040

Reference yield:

: 401518-65-8
methyl 3-{4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]piperidin-1-yl}propanate

: 847934-43-4
3-[4-cyano-4-(3-cyclopentyloxy-4-methoxy-phenyl)-piperidin-1-yl]-N-(1-methoxy-1-methyl-ethoxy)-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / aq. NaOH / methanol / 3.5 h / 20 °C

2: 190 mg / Et₃N; EDC*HCl; HOBt / dimethylformamide / 24 h / 20 °C

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.07.040