Technology Process of 3-[5-({3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]pyridine
There total 9 articles about 3-[5-({3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]pyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Burgess Reagent; N-ethyl-N,N-diisopropylamine; HATU;
In
tetrahydrofuran;
at 20 ℃;
for 0.75h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: N,N-dimethyl-formamide / 20 °C
2.1: boron tribromide / dichloromethane / 20 °C
2.2: 20 °C
3.1: sodium t-butanolate / tetrahydrofuran / 0.25 h / 0 - 20 °C
3.2: 3 h / 20 °C
4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
4.2: 0 - 20 °C
4.3: 20 °C
5.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 - 60 °C
6.1: sodium dithionite; water / tetrahydrofuran / 1 h / 20 °C
7.1: tert.-butylnitrite; copper dichloride / acetonitrile / 0.25 h / 50 °C
8.1: hydrazine / ethanol / 23 h / Reflux
9.1: Burgess Reagent; N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0.75 h / 20 °C
With
tert.-butylnitrite; sodium dithionite; Burgess Reagent; water; boron tribromide; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; copper dichloride; sodium t-butanolate; hydrazine;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: boron tribromide / dichloromethane / 20 °C
1.2: 20 °C
2.1: sodium t-butanolate / tetrahydrofuran / 0.25 h / 0 - 20 °C
2.2: 3 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
3.2: 0 - 20 °C
3.3: 20 °C
4.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 - 60 °C
5.1: sodium dithionite; water / tetrahydrofuran / 1 h / 20 °C
6.1: tert.-butylnitrite; copper dichloride / acetonitrile / 0.25 h / 50 °C
7.1: hydrazine / ethanol / 23 h / Reflux
8.1: Burgess Reagent; N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0.75 h / 20 °C
With
tert.-butylnitrite; sodium dithionite; Burgess Reagent; water; boron tribromide; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; copper dichloride; sodium t-butanolate; hydrazine;
In
tetrahydrofuran; ethanol; dichloromethane; acetonitrile; mineral oil;
