5-(2-phthalimidyl-3-methyl butanoylamino)isophthalic acid

Base Information

• Chemical Name: 5-(2-phthalimidyl-3-methyl butanoylamino)isophthalic acid
• CAS No.: 950730-96-8
• Molecular Formula: C₂₁H₁₈N₂O₇
• Molecular Weight: 410.383
• Mol file: 950730-96-8.mol

Synonyms:5-(2-phthalimidyl-3-methyl butanoylamino)isophthalic acid

Chemical Property of 5-(2-phthalimidyl-3-methyl butanoylamino)isophthalic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-phthalimidyl-3-methyl butanoylamino)isophthalic acid

There total 4 articles about 5-(2-phthalimidyl-3-methyl butanoylamino)isophthalic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.8%

5-aminoisophthalic acid (99-31-0) + N-phthalimide l-valinyl chloride (5511-73-9) → 5-(2-phthalimidyl-3-methyl butanoylamino)isophthalic acid (950730-96-8)

Guidance literature:

5-aminoisophthalic acid; N-phthalimide l-valinyl chloride; In N,N-dimethyl acetamide; at 20 ℃; for 10h;

With triethylamine; In N,N-dimethyl acetamide; at 80 ℃; for 4h;

DOI:10.3390/molecules17078255

Reference yield:

phthalic anhydride (85-44-9) → 5-(2-phthalimidyl-3-methyl butanoylamino)isophthalic acid (950730-96-8)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 12 h / Reflux

2: thionyl chloride / dichloromethane

3: triethylamine / N,N-dimethyl acetamide / 4 h / 80 °C

With thionyl chloride; acetic acid; triethylamine; In dichloromethane; N,N-dimethyl acetamide;

DOI:10.1007/s00726-010-0799-5

Reference yield:

L-valine (72-18-4,25609-85-2,7004-03-7,921-10-8) → 5-(2-phthalimidyl-3-methyl butanoylamino)isophthalic acid (950730-96-8)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 12 h / Reflux

2: thionyl chloride / dichloromethane

3: triethylamine / N,N-dimethyl acetamide / 4 h / 80 °C

With thionyl chloride; acetic acid; triethylamine; In dichloromethane; N,N-dimethyl acetamide;

DOI:10.1007/s00726-010-0799-5

upstream raw materials:

phthalic anhydride

L-valine

5-aminoisophthalic acid

N-phthalimide l-valinyl chloride