tert-Butyl 3-[{6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}(methyl)amino]benzoate

Base Information

Chemical Name:tert-Butyl 3-[{6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}(methyl)amino]benzoate
CAS No.:1246247-68-6
Molecular Formula:C₃₉H₅₂N₄O₅
Molecular Weight:656.866
Hs Code.:

Synonyms:tert-Butyl 3-[{6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}(methyl)amino]benzoate

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Chemical Property of tert-Butyl 3-[{6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}(methyl)amino]benzoate

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Technology Process of tert-Butyl 3-[{6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}(methyl)amino]benzoate

There total 5 articles about tert-Butyl 3-[{6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}(methyl)amino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1246247-66-4
tert-Butyl 3-({6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}amino)benzoate

: 1246247-68-6
tert-Butyl 3-[{6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}(methyl)amino]benzoate

Guidance literature:: formaldehyd; tert-Butyl 3-({6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}amino)benzoate; With sodium tris(acetoxy)borohydride; In ethanol; at 20 ℃; for 16h; Inert atmosphere;

With sodium hydrogencarbonate; In ethanol; water;

Reference yield:

: 22809-37-6
6-bromohexanoyl chloride

: 1246247-68-6
tert-Butyl 3-[{6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}(methyl)amino]benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0.33 h / 20 °C / Cooling with ice

1.2: 15.5 h / 60 °C

1.3: 2 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 1 h / 20 °C / Cooling with ice

3.1: sodium tris(acetoxy)borohydride / ethanol / 16 h / 20 °C / Inert atmosphere

4.1: sodium tris(acetoxy)borohydride / ethanol / 16 h / 20 °C / Inert atmosphere

With sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; triethylamine; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 864765-63-9
Biphenyl-2-ylcarbamic Acid 1-{2-[Methyl-(6-oxohexanoyl)-amino]ethyl}piperidin-4-yl Ester

: 1246247-68-6
tert-Butyl 3-[{6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}(methyl)amino]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / ethanol / 16 h / 20 °C / Inert atmosphere

2: sodium tris(acetoxy)borohydride / ethanol / 16 h / 20 °C / Inert atmosphere

With sodium tris(acetoxy)borohydride; In ethanol;