(1S,2R,4R)-2-methoxy-4-methyl-1-(prop-1-en-2-yl)cyclohexane

Base Information

• Chemical Name: (1S,2R,4R)-2-methoxy-4-methyl-1-(prop-1-en-2-yl)cyclohexane
• CAS No.: 1186421-97-5
• Molecular Formula: C₁₁H₂₀O
• Molecular Weight: 168.279
• Mol file: 1186421-97-5.mol

Synonyms:(1S,2R,4R)-2-methoxy-4-methyl-1-(prop-1-en-2-yl)cyclohexane

Chemical Property of (1S,2R,4R)-2-methoxy-4-methyl-1-(prop-1-en-2-yl)cyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

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Technology Process of (1S,2R,4R)-2-methoxy-4-methyl-1-(prop-1-en-2-yl)cyclohexane

There total 1 articles about (1S,2R,4R)-2-methoxy-4-methyl-1-(prop-1-en-2-yl)cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

isopulegol (7786-67-6,18674-65-2,20549-46-6,21290-09-5,29141-10-4,50373-36-9,59905-53-2,59905-54-3,96612-21-4,104870-56-6,121468-66-4,122517-60-6,122517-61-7,144541-38-8,89-79-2) + methyl iodide (74-88-4) → (1S,2R,4R)-2-methoxy-4-methyl-1-(prop-1-en-2-yl)cyclohexane (1186421-97-5)

Guidance literature:

isopulegol; With sodium hydride; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jo901111j

Reference yield: 78.0%

(1S,2R,4R)-2-methoxy-4-methyl-1-(prop-1-en-2-yl)cyclohexane (1186421-97-5) + 1-methylcyclohexa-2,5-diene-1-carbonitrile → 3-((1S,2R,4R)-2-methoxy-4-methylcyclohexyl)butanenitrile

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tris(pentafluorophenyl)borate; bis[2-(diphenylphosphino)phenyl] ether; In 1,4-dioxane; at 110 ℃; for 20h; diastereoselective reaction; Glovebox; Inert atmosphere;

DOI:10.1021/jacs.8b10651

Reference yield:

(1S,2R,4R)-2-methoxy-4-methyl-1-(prop-1-en-2-yl)cyclohexane (1186421-97-5) + (E)-2-(4-methylphenyl)-1-nitroethene (101671-00-5,5153-68-4) → C17H24O + C17H24O

Guidance literature:

(1S,2R,4R)-2-methoxy-4-methyl-1-(prop-1-en-2-yl)cyclohexane; With ozone; In methanol; at -78 ℃;

(E)-2-(4-methylphenyl)-1-nitroethene; With ferrous(II) sulfate heptahydrate; In methanol; at 0 ℃; Overall yield = 72 percent; Overall yield = 81.4 mg; stereoselective reaction; Inert atmosphere;

DOI:10.1002/anie.202005267

upstream raw materials:

isopulegol

methyl iodide