ethyl 2-(4-(4-chlorophenyl)-3-cyano-6-(thien-2-yl)pyridin-2-yloxy)acetate

Base Information

• Chemical Name: ethyl 2-(4-(4-chlorophenyl)-3-cyano-6-(thien-2-yl)pyridin-2-yloxy)acetate
• CAS No.: 1421755-83-0
• Molecular Formula: C₂₀H₁₅ClN₂O₃S
• Molecular Weight: 398.87

Synonyms:ethyl 2-(4-(4-chlorophenyl)-3-cyano-6-(thien-2-yl)pyridin-2-yloxy)acetate

Chemical Property of ethyl 2-(4-(4-chlorophenyl)-3-cyano-6-(thien-2-yl)pyridin-2-yloxy)acetate

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Technology Process of ethyl 2-(4-(4-chlorophenyl)-3-cyano-6-(thien-2-yl)pyridin-2-yloxy)acetate

There total 1 articles about ethyl 2-(4-(4-chlorophenyl)-3-cyano-6-(thien-2-yl)pyridin-2-yloxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(4-chlorophenyl)-2-oxo-6-(thien-2-yl)-1,2-dihydropyridine-3-carbonitrile (120238-95-1) + ethyl bromoacetate (105-36-2) → ethyl 2-(4-(4-chlorophenyl)-3-cyano-6-(thien-2-yl)pyridin-2-yloxy)acetate (1421755-83-0)

Guidance literature:

4-(4-chlorophenyl)-2-oxo-6-(thien-2-yl)-1,2-dihydropyridine-3-carbonitrile; With potassium carbonate; In N,N-dimethyl-formamide; for 1h;

ethyl bromoacetate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1007/s11164-012-1006-y

Reference yield: 80.0%

ethyl 2-(4-(4-chlorophenyl)-3-cyano-6-(thien-2-yl)pyridin-2-yloxy)acetate (1421755-83-0) → 2-(4-(4-chlorophenyl)-3-cyano-6-(thien-2-yl)pyridin-2-yloxy)acetohydrazide (1421755-84-1)

Guidance literature:

With hydrazine hydrate; In ethanol; for 1h; Reflux;

DOI:10.1007/s11164-012-1006-y

Reference yield: 78.0%

ethyl 2-(4-(4-chlorophenyl)-3-cyano-6-(thien-2-yl)pyridin-2-yloxy)acetate (1421755-83-0) → ethyl 3-amino-4-(4-chlorophenyl)-6-(thien-2-yl)furo[2,3-b]pyridine-2-carboxylate (1421755-85-2)

Guidance literature:

With sodium methylate; In methanol; for 0.5h; Reflux;

DOI:10.1007/s11164-012-1006-y

upstream raw materials:

4-(4-chlorophenyl)-2-oxo-6-(thien-2-yl)-1,2-dihydropyridine-3-carbonitrile

ethyl bromoacetate

Downstream raw materials:

2-(4-(4-chlorophenyl)-3-cyano-6-(thien-2-yl)pyridin-2-yloxy)acetohydrazide

ethyl 3-amino-4-(4-chlorophenyl)-6-(thien-2-yl)furo[2,3-b]pyridine-2-carboxylate

5-(3-amino-4-(4-chlorophenyl)-6-(thien-2-yl)furo[2,3-b]pyridin-2-yl)-4H-1,2,4-triazole-3-thiol

3-allyl-9-(4-chlorophenyl)-4-oxo-1,2,3,4-tetrahydro-7-(thien-2-yl)-2-thioxopyrido[3',2':4,5]furo-[3,2-d]pyrimidine

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