N-(3-chlorophenyl)acrylamide

Base Information

• Chemical Name: N-(3-chlorophenyl)acrylamide
• CAS No.: 7017-16-5
• Molecular Formula: C9H8ClNO
• Molecular Weight: 181.622
• Hs Code.: 2924299090
• Mol file: 7017-16-5.mol

Synonyms:Acrylsaeure-<3-amino-propylester>;acrylic acid 3-aminopropyl ester;2-Propenoic acid,3-aminopropyl ester;

Chemical Property of N-(3-chlorophenyl)acrylamide

Chemical Property:

• Vapor Pressure: 0.000111mmHg at 25°C
• Melting Point: 106-107 °C
• Boiling Point: 336.6°Cat760mmHg
• PKA: 12.97±0.70(Predicted)
• Flash Point: 157.4°C
• PSA: 29.10000
• Density: 1.243g/cm³
• LogP: 2.53750

Purity/Quality:

99% ^*data from raw suppliers

N-(3-chlorophenyl)prop-2-enamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3-chlorophenyl)acrylamide

There total 4 articles about N-(3-chlorophenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-chloro-aniline (108-42-9) + acryloyl chloride (814-68-6,25189-84-8) → N-(3-chlorophenyl)acrylamide (7017-16-5)

Guidance literature:

With potassium carbonate; In water; acetone; at 20 ℃;

DOI:10.1002/ejoc.200600700

Reference yield: 75.0%

C10H12ClNOS → N-(3-chlorophenyl)acrylamide (7017-16-5)

Guidance literature:

With Selectfluor; In 1,4-dioxane; at 110 ℃; for 12h; Schlenk technique; Sealed tube;

DOI:10.1002/ejoc.201900960

Reference yield:

3-chloro-aniline (108-42-9) → N-(3-chlorophenyl)acrylamide (7017-16-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 20 °C

2: Selectfluor / 1,4-dioxane / 12 h / 110 °C / Schlenk technique; Sealed tube

With Selectfluor; In 1,4-dioxane; dichloromethane;

DOI:10.1002/ejoc.201900960

upstream raw materials:

3-chloro-aniline

acryloyl chloride

Refernces

• 1、 Hou, Fei,Du, Xing-Peng,Alduma, Anwar I.,Li, Zhi-Feng,Huo, Cong-De,Wang, Xi-Cun,Wu, Xiao-Feng,Quan, Zheng-Jun. "Disulfide Promoted C?P Bond Cleavage of Phosphoramide: “P” Surrogates to Synthesize Phosphonates and Phosphinates". supporting information. p. 4755 - 4760. Retrieved 2020/10/06.
• 2、 Yang, Ke,Li, Yi,Ma, Zhiyan,Tang, Long,Yin, Yue,Zhang, Hao,Li, Zhengyi,Sun, Xiaoqiang. "Metal-Free C–S Bond Cleavage to Access N-Substituted Acrylamide and β-Aminopropanamide". . p. 5812 - 5814. Retrieved 2019/08/27.