2-{3-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-isoxazol-5-yl}-5-trifluoromethyl-benzonitrile

Base Information

Chemical Name:2-{3-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-isoxazol-5-yl}-5-trifluoromethyl-benzonitrile
CAS No.:1234790-74-9
Molecular Formula:C₂₃H₁₁F₅N₆O
Molecular Weight:482.372
Hs Code.:

Synonyms:2-{3-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-isoxazol-5-yl}-5-trifluoromethyl-benzonitrile

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Chemical Property of 2-{3-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-isoxazol-5-yl}-5-trifluoromethyl-benzonitrile

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Technology Process of 2-{3-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-isoxazol-5-yl}-5-trifluoromethyl-benzonitrile

There total 5 articles about 2-{3-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-isoxazol-5-yl}-5-trifluoromethyl-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1186482-07-4
2-(2,3-difluoro-phenyl)-1H-imidazo[4,5-d]pyridazine

: 1234790-91-0
C₁₃H₉F₃N₂O₄S

: 1234790-74-9
2-{3-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-isoxazol-5-yl}-5-trifluoromethyl-benzonitrile

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 93 ℃; Sonographic reaction;

Reference yield:

: 1483-55-2
2-bromo-5-trifluoromethylbenzonitrile

: 1234790-74-9
2-{3-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-isoxazol-5-yl}-5-trifluoromethyl-benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: copper(l) iodide; triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 4 h / 80 °C / Inert atmosphere

2: methanol; potassium carbonate / 2 h / 20 °C

3: phenyl isocyanate; N-ethyl-N,N-diisopropylamine / toluene / 5 h / 85 °C

4: acetic acid / tetrahydrofuran; water / 1 h / 93 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / Heating; Inert atmosphere

6: potassium carbonate / N,N-dimethyl-formamide / 93 °C / Sonographic reaction

With methanol; copper(l) iodide; potassium carbonate; phenyl isocyanate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: C₁₃H₁₂F₃NSi

: 1234790-74-9
2-{3-[2-(2,3-difluoro-phenyl)-imidazo[4,5-d]pyridazin-5-ylmethyl]-isoxazol-5-yl}-5-trifluoromethyl-benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: methanol; potassium carbonate / 2 h / 20 °C

2: phenyl isocyanate; N-ethyl-N,N-diisopropylamine / toluene / 5 h / 85 °C

3: acetic acid / tetrahydrofuran; water / 1 h / 93 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / Heating; Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 93 °C / Sonographic reaction

With methanol; potassium carbonate; phenyl isocyanate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;