N-{3-[4-(heptyl-methyl-amino)-phenyl]-1,1-bis-hydroxymethyl-propyl}-acetamide

Base Information

Chemical Name:N-{3-[4-(heptyl-methyl-amino)-phenyl]-1,1-bis-hydroxymethyl-propyl}-acetamide
CAS No.:1027989-08-7
Molecular Formula:C₂₁H₃₆N₂O₃
Molecular Weight:364.528
Hs Code.:

<i>N</i>-{3-[4-(heptyl-methyl-amino)-phenyl]-1,1-bis-hydroxymethyl-propyl}-acetamide

Synonyms:N-{3-[4-(heptyl-methyl-amino)-phenyl]-1,1-bis-hydroxymethyl-propyl}-acetamide

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Chemical Property of N-{3-[4-(heptyl-methyl-amino)-phenyl]-1,1-bis-hydroxymethyl-propyl}-acetamide

Chemical Property:

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Technology Process of N-{3-[4-(heptyl-methyl-amino)-phenyl]-1,1-bis-hydroxymethyl-propyl}-acetamide

There total 11 articles about N-{3-[4-(heptyl-methyl-amino)-phenyl]-1,1-bis-hydroxymethyl-propyl}-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 162358-55-6
2-acetylamino-2-{2-[4-(heptyl-methyl-amino)-phenyl]-ethyl}-malonic acid diethyl ester

: 1027989-08-7
N-{3-[4-(heptyl-methyl-amino)-phenyl]-1,1-bis-hydroxymethyl-propyl}-acetamide

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm000173z

Reference yield:

: 2528-61-2
Heptanoic acid chloride

: 1027989-08-7
N-{3-[4-(heptyl-methyl-amino)-phenyl]-1,1-bis-hydroxymethyl-propyl}-acetamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: 52 percent / Et₃N / tetrahydrofuran / 3 h / 20 °C

2.1: p-TsOH*H₂O / tetrahydrofuran; CH₂Cl₂ / 7 h / 20 °C

3.1: 5.95 g / potassium tert-butoxide / 1,2-dimethoxy-ethane / 1 h / 60 °C

4.1: BH₃*THF / tetrahydrofuran / 3 h / 0 °C

5.1: 3.22 g / p-TsOH*H₂O; MeOH / 3 h / 20 °C

6.1: Et₃N / CH₂Cl₂ / 1 h / 20 °C

7.1: 2.58 g / NaI / butan-2-one / 2 h / Heating

8.1: sodium ethoxide / ethanol / 0.5 h / 20 °C

8.2: ethanol / 3 h / 65 °C

9.1: LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

With methanol; lithium aluminium tetrahydride; borane-THF; potassium tert-butylate; sodium ethanolate; toluene-4-sulfonic acid; triethylamine; sodium iodide; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; butanone; 1.1: Acylation / 2.1: Addition / 3.1: Methylation / 4.1: Reduction / 5.1: methanolysis / 6.1: mesylation / 7.1: Iodination / 8.1: Metallation / 8.2: Alkylation / 9.1: Reduction;
DOI:10.1021/jm000173z

Reference yield:

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 1027989-08-7
N-{3-[4-(heptyl-methyl-amino)-phenyl]-1,1-bis-hydroxymethyl-propyl}-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium ethoxide / ethanol / 0.5 h / 20 °C

1.2: ethanol / 3 h / 65 °C

2.1: LiAlH₄ / tetrahydrofuran / 2 h / 20 °C

With lithium aluminium tetrahydride; sodium ethanolate; In tetrahydrofuran; ethanol; 1.1: Metallation / 1.2: Alkylation / 2.1: Reduction;
DOI:10.1021/jm000173z